› 1an2

X-ray diffraction
2.9Å resolution

RECOGNITION BY MAX OF ITS COGNATE DNA THROUGH A DIMERIC B/HLH/Z DOMAIN

Released:
DOI: 10.2210/pdb1an2/pdb
PDB entry 1an2 coloured by chain, front view.
PDB entry 1an2 coloured by chain, side view.
PDB entry 1an2 coloured by chain, top view.
Source organisms:
Primary publication:
Recognition by Max of its cognate DNA through a dimeric b/HLH/Z domain.
Ferré-D'Amaré AR, Prendergast GC, Ziff EB, Burley SK
Nature 363 38-45 (1993)
PMID: 8479534

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113429 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Protein max Chain: A
Molecule details ›
Chain: A
Length: 86 amino acids
Theoretical weight: 10.22 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P61244 (Residues: 22-107; Coverage: 54%)
Gene names: BHLHD4, MAX
Sequence domains: Helix-loop-helix DNA-binding domain
Structure domains: Helix-loop-helix DNA-binding domain
DNA (5'-D(*GP*TP*GP*TP*AP*GP*GP*TP*CP*AP*CP*GP*TP*GP*AP*CP*C P*TP*AP*CP*AP*C)- 3') Chain: B
Molecule details ›
Chain: B
Length: 22 nucleotides
Theoretical weight: 6.75 KDa
Source organism: Mus musculus
Expression system: Escherichia coli

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P6122
Unit cell:
a: 72.2Å b: 72.2Å c: 146.4Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.232 0.232 not available
Expression systems:
  • Not provided
  • Escherichia coli

Quick links

Citations

52 review citations

Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms.
Massari et al. (2000)
51 more

26 mentions without citation

An overview of the basic helix-loop-helix proteins.
Jones S. (2004)
25 more