PDBe 1an1

X-ray diffraction
2.03Å resolution

LEECH-DERIVED TRYPTASE INHIBITOR/TRYPSIN COMPLEX

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Trypsin Chain: E
Molecule details ›
Chain: E
Length: 223 amino acids
Theoretical weight: 23.49 KDa
Source organism: Sus scrofa
Expression system: Not provided
UniProt:
  • Canonical: P00761 (Residues: 9-231; Coverage: 97%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Leech-derived tryptase inhibitor C Chain: I
Molecule details ›
Chain: I
Length: 46 amino acids
Theoretical weight: 4.75 KDa
Source organism: Hirudo medicinalis
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P80424 (Residues: 1-46; Coverage: 100%)
Sequence domains: Kazal-type serine protease inhibitor domain
Structure domains: Wheat Germ Agglutinin (Isolectin 2); domain 1

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR591
Spacegroup: P43212
Unit cell:
a: 63.7Å b: 63.7Å c: 130.86Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.17 0.17 0.228
Expression systems:
  • Not provided
  • Saccharomyces cerevisiae