› 193d

Solution NMR

SOLUTION STRUCTURE OF A QUINOMYCIN BISINTERCALATOR-DNA COMPLEX

Released:
DOI: 10.2210/pdb193d/pdb
PDB entry 193d coloured by chain, ensemble of 4 models, front view.
PDB entry 193d coloured by chain, ensemble of 4 models, side view.
PDB entry 193d coloured by chain, ensemble of 4 models, top view.
Source organisms:
Primary publication:
Solution structure of a quinomycin bisintercalator-DNA complex.
Chen H, Patel DJ
J Mol Biol 246 164-79 (1995)
PMID: 7853395

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-113371 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
QUINOMYCIN Chain: C
Molecule details ›
Chain: C
Length: 8 amino acids
Theoretical weight: 847 Da
Source organism: Streptomyces
Expression system: Not provided
DNA (5'-D(*AP*CP*AP*CP*GP*TP*GP*T)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 8 nucleotides
Theoretical weight: 2.43 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand HQU 2 x HQU
3 modified residues:
Ligand DSN 2 x DSN
Ligand NYB 1 x NYB
Ligand CPC 2 x CPC

Experiments and Validation Details

Entry percentile scores
Refinement method: MOLECULAR DYNAMICS, MATRIX RELAXATION
Expression system: Not provided

Quick links

Citations

2 review citations

Recent developments in bisintercalator natural products.
Zolova et al. (2010)
1 more

2 mentions without citation

A new quinoxaline-containing peptide induces apoptosis in cancer cells by autophagy modulation.
Zamudio-Vázquez et al. (2015)
1 more