› 16vp

X-ray diffraction
2.1Å resolution

CONSERVED CORE OF THE HERPES SIMPLEX VIRUS TRANSCRIPTIONAL REGULATORY PROTEIN VP16

Released:
DOI: 10.2210/pdb16vp/pdb
PDB entry 16vp coloured by chain, front view.
PDB entry 16vp coloured by chain, side view.
PDB entry 16vp coloured by chain, top view.
Source organism: Human alphaherpesvirus 1
Primary publication:
Crystal structure of the conserved core of the herpes simplex virus transcriptional regulatory protein VP16.
Liu Y, Gong W, Huang CC, Herr W, Cheng X
Genes Dev 13 1692-703 (1999)
PMID: 10398682

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139060 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tegument protein VP16 Chain: A
Molecule details ›
Chain: A
Length: 366 amino acids
Theoretical weight: 41.48 KDa
Source organism: Human alphaherpesvirus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: P06492 (Residues: 49-412; Coverage: 74%)
Gene name: UL48
Sequence domains: Alpha trans-inducing protein (Alpha-TIF)
Structure domains: Alpha trans-inducing (Alpha-TIF)

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: P212121
Unit cell:
a: 59.5Å b: 77.1Å c: 84Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.192 0.26
Expression system: Escherichia coli

Quick links

Citations

11 review citations

The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
Wysocka et al. (2003)
10 more

3 mentions without citation

Crystal structure of the conserved core of the herpes simplex virus transcriptional regulatory protein VP16.
Liu et al. (1999)
2 more