EMD-9869

Single-particle
2.9 Å
EMD-9869
3D View Gallery
Deposition: 26/03/2019
Map released: 12/06/2019
Last modified: 15/11/2023
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links

EMD-9869
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 6jpb summary report (pdf.gz) Map and 6jpb FULL report (pdf.gz)
EMICSS annotations (xml)

Rabbit Cav1.1-Diltiazem Complex

EMD-9869

Single-particle
2.9 Å
EMD-9869
3D View Gallery
Deposition: 26/03/2019
Map released: 12/06/2019
Last modified: 15/11/2023
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Name: Cav1.1-drug complex
Complex [2]
Name: Cav1.1-drug complex
Complex Portal [3]
ID Name Overlap
CPX-3189 Cav1.1 voltage-gated calcium channel complex, CACNA2D1-CACNB1-CACNG1 variant 0.75
CPX-3189 Skeletal muscle VGCC complex 0.75
CPX-3189 Skeletal muscle VGCC complex 0.50
Name: Cav1.1-beta1a-alpha2-delta1-gamma complex
Natural source [1]
Organism: Oryctolagus cuniculus
Complex Portal [3]
ID Name Overlap
CPX-3189 Cav1.1 voltage-gated calcium channel complex, CACNA2D1-CACNB1-CACNG1 variant 1.00
CPX-3189 Skeletal muscle VGCC complex 1.00
CPX-3189 Skeletal muscle VGCC complex 0.75
Protein [5]
LEVO
Name: Voltage-dependent L-type calcium channel subunit alpha-1S
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [14]
Biological process:
muscle contraction release of sequestered calcium ion into cytosol positive regulation of muscle contraction regulation of ryanodine-sensitive calcium-release channel activity cellular response to caffeine calcium ion transmembrane transport
Molecular function:
calmodulin binding transmembrane transporter binding voltage-gated calcium channel activity metal ion binding
Cellular location:
plasma membrane integral component of plasma membrane L-type voltage-gated calcium channel complex T-tubule
Natural source
Organism: Oryctolagus cuniculus
Molecular weight
Experimental Theoretical Method
- 212 kDa -
LEVO
Name: Voltage-dependent calcium channel gamma-1 subunit
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [10]
Biological process:
calcium ion transmembrane transport positive regulation of muscle contraction regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
Molecular function:
voltage-gated calcium channel activity calcium channel regulator activity
Cellular location:
plasma membrane integral component of plasma membrane sarcolemma L-type voltage-gated calcium channel complex T-tubule
Natural source
Organism: Oryctolagus cuniculus
Molecular weight
Experimental Theoretical Method
- 25 kDa -
LEVO
Name: Voltage-dependent L-type calcium channel subunit beta-1
Number of copies: 1
UniProtKB UniProtKB UniProtKB PDBe-KB PDBe-KB PDBe-KB AlphaFold DB AlphaFold DB AlphaFold DB
Domains
Gene Ontology [5]
Biological process:
positive regulation of muscle contraction calcium ion transmembrane transport
Molecular function:
voltage-gated calcium channel activity
Cellular location:
T-tubule L-type voltage-gated calcium channel complex
Natural source
Organism: Oryctolagus cuniculus
Molecular weight
Experimental Theoretical Method
- 49 kDa -
Recombinant Expression
Organism Strain Cell Plasmid
Escherichia coli - - -
LEVO
Name: Voltage-dependent L-type calcium channel subunit beta-1
Number of copies: 1
UniProtKB UniProtKB UniProtKB PDBe-KB PDBe-KB PDBe-KB AlphaFold DB AlphaFold DB AlphaFold DB
Domains
Gene Ontology [5]
Biological process:
calcium ion transmembrane transport positive regulation of muscle contraction
Molecular function:
voltage-gated calcium channel activity
Cellular location:
L-type voltage-gated calcium channel complex T-tubule
Natural source
Organism: Oryctolagus cuniculus
Molecular weight
Experimental Theoretical Method
- 57 kDa -
LEVO
Name: Voltage-dependent calcium channel subunit alpha-2/delta-1
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [11]
Biological process:
regulation of monoatomic ion transmembrane transport calcium ion transmembrane transport regulation of ion transmembrane transport calcium ion import across plasma membrane
Molecular function:
voltage-gated monoatomic ion channel activity metal ion binding calcium channel regulator activity calcium channel activity voltage-gated ion channel activity
Cellular location:
L-type voltage-gated calcium channel complex T-tubule
Natural source
Organism: Oryctolagus cuniculus
Molecular weight
Experimental Theoretical Method
- 118 kDa -
Ligand [6]
Name: 2-acetamido-2-deoxy-beta-D-glucopyranose
HET code: NAG
Number of copies: 8
ChEMBL ChEBI
Molecular weight
Experimental Theoretical Method
- 221 Da -
Name: CALCIUM ION
HET code: CA
Number of copies: 3
ChEBI DrugBank
Molecular weight
Experimental Theoretical Method
- 40 Da -
Name: 1,2-Distearoyl-sn-glycerophosphoethanolamine
HET code: 3PE
Number of copies: 4
ChEBI
Molecular weight
Experimental Theoretical Method
- 748 Da -
Name: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE
HET code: PC1
Number of copies: 1
ChEBI
Molecular weight
Experimental Theoretical Method
- 790 Da -
Name: Diltiazem
HET code: C9F
Number of copies: 1
ChEMBL ChEMBL ChEBI ChEBI DrugBank DrugBank
Molecular weight
Experimental Theoretical Method
- 414 Da -
Name: ETHANOLAMINE
HET code: ETA
Number of copies: 1
ChEMBL ChEBI DrugBank
Molecular weight
Experimental Theoretical Method
- 61 Da -