EMD-9868 Function and Biology

Rabbit Cav1.1-Verapamil Complex

Single particle reconstruction
2.6Å resolution
Overview of EMD-9868
Sample name: Cav1.1-drug complex
Number of unique components: 15

Cav1.1-drug complex

Protein type
Name: Cav1.1-drug complex

Cav1.1-beta1a-alpha2-delta1-gamma complex [Oryctolagus cuniculus]

Protein type
Name: Cav1.1-beta1a-alpha2-delta1-gamma complex

Voltage-dependent L-type calcium channel subunit alpha-1S [Rabbit]

Protein type
Name: Voltage-dependent L-type calcium channel subunit alpha-1S
Theoretical weight (MDa): 0.172
Number of copies: 1

Voltage-dependent calcium channel gamma-1 subunit [Rabbit]

Protein type
Name: Voltage-dependent calcium channel gamma-1 subunit
Theoretical weight (MDa): 0.025
Number of copies: 1

Voltage-dependent L-type calcium channel subunit beta-1 [Oryctolagus cuniculus]

Protein type
Name: Voltage-dependent L-type calcium channel subunit beta-1
Theoretical weight (MDa): 0.05
Number of copies: 1
Expression system
Expression system: Escherichia coli

Voltage-dependent L-type calcium channel subunit beta-1 [Rabbit]

Protein type
Name: Voltage-dependent L-type calcium channel subunit beta-1
Theoretical weight (MDa): 0.058
Number of copies: 1

Voltage-dependent calcium channel subunit alpha-2/delta-1 [Rabbit]

Protein type
Name: Voltage-dependent calcium channel subunit alpha-2/delta-1
Theoretical weight (MDa): 0.119
Number of copies: 1

N-ACETYL-D-GLUCOSAMINE

Ligand type
Name: N-ACETYL-D-GLUCOSAMINE
Theoretical weight (MDa): 0
Number of copies: 23

CALCIUM ION

Ligand type
Name: CALCIUM ION
Theoretical weight (MDa): 0
Number of copies: 3

1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE

Ligand type
Name: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE
Theoretical weight (MDa): 0.001
Number of copies: 8

1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE

Ligand type
Name: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE
Theoretical weight (MDa): 0.001
Number of copies: 2

(3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en

Ligand type
Name: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en
Theoretical weight (MDa): 0.001
Number of copies: 1

(2S)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile

Ligand type
Name: (2S)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile
Theoretical weight (MDa): 0
Number of copies: 2

ETHANOLAMINE

Ligand type
Name: ETHANOLAMINE
Theoretical weight (MDa): 0
Number of copies: 1

BETA-D-MANNOSE

Ligand type
Name: BETA-D-MANNOSE
Theoretical weight (MDa): 0
Number of copies: 2