EMD-8859
The complete structure of the small subunit processome
EMD-8859
Single-particle3.8 Å
Deposition: 26/07/2017Map released: 27/09/2017
Last modified: 13/03/2024
Name: Small subunit processome
Summary:
- Complex
- RNA
- Protein
- rpS18_uS13
- rpS4_eS4
- rpS5_uS7
- rpS6_eS6
- rpS7_eS7
- rpS8_eS8
- rpS9_uS4
- rpS16_uS9
- rpS11_uS17
- rpS22_uS8
- rpS24_eS24
- rpS28_eS28
- Utp17
- Utp8
- Utp15
- Utp9
- Utp5
- Utp10
- Utp4
- Utp1
- Utp6
- Utp12
- Utp13
- Utp18
- Utp21
- Sof1
- Enp2
- Utp7
- Kre33
- Imp3
- Mpp10
- Sas10
- Lcp5
- Bud21
- Faf1
- rpS13_uS15
- rpS14_uS11
- Utp22
- Rrp7
- Rrp5
- Krr1
- Nop56
- Nop58
- Nop1
- Snu13
- Rrp9
- Rcl1
- Bms1
- Emg1
- Utp24
- Imp4
- Utp30
- Pno1
- Utp20
- Fcf2
- rpS23_uS12
- Utp14
- Nop14
- Noc4
- Rrt14
- Unassigned peptides
- Utp11
- Enp1
- Ligand
Name: 5' ETS
Number of copies: 1
Number of copies: 1
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 225 kDa | - |
Name: 18S pre-rRNA
Number of copies: 1
Number of copies: 1
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 582 kDa | - |
Name: U3 snoRNA
Number of copies: 1
Number of copies: 1
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 106 kDa | - |
Name: rpS18_uS13
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [9]
Biological process:
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cytoplasmic translation
Molecular function:
structural constituent of ribosome rRNA binding
Cellular location:
small ribosomal subunit cytosolic small ribosomal subunit cytoplasm mitochondrion cytosol
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cytoplasmic translation
Molecular function:
structural constituent of ribosome rRNA binding
Cellular location:
small ribosomal subunit cytosolic small ribosomal subunit cytoplasm mitochondrion cytosol
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 16 kDa | - |
Name: rpS4_eS4
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [9]
Biological process:
cytoplasmic translation translation
Molecular function:
RNA binding rRNA binding structural constituent of ribosome
Cellular location:
cytosolic small ribosomal subunit cytosol cytoplasm 90S preribosome
cytoplasmic translation translation
Molecular function:
RNA binding rRNA binding structural constituent of ribosome
Cellular location:
cytosolic small ribosomal subunit cytosol cytoplasm 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 29 kDa | - |
Name: rpS5_uS7
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [4]
Biological process:
translation
Molecular function:
RNA binding structural constituent of ribosome
Cellular location:
small ribosomal subunit
translation
Molecular function:
RNA binding structural constituent of ribosome
Cellular location:
small ribosomal subunit
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 25 kDa | - |
Name: rpS6_eS6
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [9]
Biological process:
translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
structural constituent of ribosome
Cellular location:
cytosol nucleolus 90S preribosome small-subunit processome nucleoplasm cytosolic small ribosomal subunit
translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
structural constituent of ribosome
Cellular location:
cytosol nucleolus 90S preribosome small-subunit processome nucleoplasm cytosolic small ribosomal subunit
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 27 kDa | - |
Name: rpS7_eS7
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [11]
Biological process:
ribosomal small subunit biogenesis cytoplasmic translation rRNA processing ribosome biogenesis
Molecular function:
structural constituent of ribosome
Cellular location:
small-subunit processome cytosol nucleolus nucleoplasm 90S preribosome cytosolic small ribosomal subunit
ribosomal small subunit biogenesis cytoplasmic translation rRNA processing ribosome biogenesis
Molecular function:
structural constituent of ribosome
Cellular location:
small-subunit processome cytosol nucleolus nucleoplasm 90S preribosome cytosolic small ribosomal subunit
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 21 kDa | - |
Name: rpS8_eS8
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [6]
Biological process:
translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
structural constituent of ribosome
Cellular location:
cytosol cytosolic small ribosomal subunit 90S preribosome
translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
structural constituent of ribosome
Cellular location:
cytosol cytosolic small ribosomal subunit 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 22 kDa | - |
Name: rpS9_uS4
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [12]
Biological process:
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) translation ribosomal small subunit biogenesis
Molecular function:
structural constituent of ribosome rRNA binding
Cellular location:
cytoplasm small-subunit processome nucleoplasm nucleolus cytosol 90S preribosome cytosolic small ribosomal subunit
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) translation ribosomal small subunit biogenesis
Molecular function:
structural constituent of ribosome rRNA binding
Cellular location:
cytoplasm small-subunit processome nucleoplasm nucleolus cytosol 90S preribosome cytosolic small ribosomal subunit
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 22 kDa | - |
Name: rpS16_uS9
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [7]
Biological process:
translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
structural constituent of ribosome RNA binding
Cellular location:
cytosol 90S preribosome cytosolic small ribosomal subunit
translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
structural constituent of ribosome RNA binding
Cellular location:
cytosol 90S preribosome cytosolic small ribosomal subunit
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 15 kDa | - |
Name: rpS11_uS17
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [8]
Biological process:
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) translation ribosomal small subunit assembly
Molecular function:
rRNA binding structural constituent of ribosome
Cellular location:
cytosolic small ribosomal subunit cytosol 90S preribosome
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) translation ribosomal small subunit assembly
Molecular function:
rRNA binding structural constituent of ribosome
Cellular location:
cytosolic small ribosomal subunit cytosol 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 17 kDa | - |
Name: rpS22_uS8
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [4]
Biological process:
cytoplasmic translation
Molecular function:
structural constituent of ribosome
Cellular location:
cytosolic small ribosomal subunit cytosol
cytoplasmic translation
Molecular function:
structural constituent of ribosome
Cellular location:
cytosolic small ribosomal subunit cytosol
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 14 kDa | - |
Name: rpS24_eS24
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [6]
Biological process:
cytoplasmic translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
structural constituent of ribosome
Cellular location:
mitochondrion cytosol cytosolic small ribosomal subunit
cytoplasmic translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
structural constituent of ribosome
Cellular location:
mitochondrion cytosol cytosolic small ribosomal subunit
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 15 kDa | - |
Name: rpS28_eS28
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [7]
Biological process:
maturation of SSU-rRNA positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay translation ribosomal small subunit assembly
Molecular function:
structural constituent of ribosome
Cellular location:
cytosol cytosolic small ribosomal subunit
maturation of SSU-rRNA positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay translation ribosomal small subunit assembly
Molecular function:
structural constituent of ribosome
Cellular location:
cytosol cytosolic small ribosomal subunit
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 7 kDa | - |
Name: Utp17
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [13]
Biological process:
positive regulation of transcription by RNA polymerase I maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) positive regulation of rRNA processing maturation of SSU-rRNA
Molecular function:
U3 snoRNA binding RNA binding mRNA binding
Cellular location:
t-UTP complex 90S preribosome rDNA heterochromatin nucleoplasm nucleolus small-subunit processome
positive regulation of transcription by RNA polymerase I maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) positive regulation of rRNA processing maturation of SSU-rRNA
Molecular function:
U3 snoRNA binding RNA binding mRNA binding
Cellular location:
t-UTP complex 90S preribosome rDNA heterochromatin nucleoplasm nucleolus small-subunit processome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 100 kDa | - |
Name: Utp8
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 65 kDa | - |
Name: Utp15
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [11]
Biological process:
maturation of SSU-rRNA rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) positive regulation of transcription by RNA polymerase I
Molecular function:
U3 snoRNA binding
Cellular location:
nucleolus small-subunit processome rDNA heterochromatin t-UTP complex nucleoplasm 90S preribosome
maturation of SSU-rRNA rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) positive regulation of transcription by RNA polymerase I
Molecular function:
U3 snoRNA binding
Cellular location:
nucleolus small-subunit processome rDNA heterochromatin t-UTP complex nucleoplasm 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 57 kDa | - |
Name: Utp9
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [10]
Biological process:
maturation of SSU-rRNA positive regulation of transcription by RNA polymerase I maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
U3 snoRNA binding
Cellular location:
t-UTP complex nucleolus 90S preribosome rDNA heterochromatin nucleus small-subunit processome
maturation of SSU-rRNA positive regulation of transcription by RNA polymerase I maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
U3 snoRNA binding
Cellular location:
t-UTP complex nucleolus 90S preribosome rDNA heterochromatin nucleus small-subunit processome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 64 kDa | - |
Name: Utp5
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [8]
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 72 kDa | - |
Name: Utp10
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [16]
Biological process:
maturation of SSU-rRNA endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) positive regulation of transcription by RNA polymerase I maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
snoRNA binding U3 snoRNA binding
Cellular location:
preribosome, small subunit precursor rDNA heterochromatin small-subunit processome nucleolus t-UTP complex mitochondrion nucleoplasm 90S preribosome
maturation of SSU-rRNA endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) positive regulation of transcription by RNA polymerase I maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
snoRNA binding U3 snoRNA binding
Cellular location:
preribosome, small subunit precursor rDNA heterochromatin small-subunit processome nucleolus t-UTP complex mitochondrion nucleoplasm 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 200 kDa | - |
Name: Utp4
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [8]
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 87 kDa | - |
Name: Utp1
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [15]
Biological process:
septum digestion after cytokinesis endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) establishment of cell polarity maturation of SSU-rRNA maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosomal small subunit assembly
Molecular function:
mRNA binding
Cellular location:
small-subunit processome Pwp2p-containing subcomplex of 90S preribosome nucleolus nucleoplasm 90S preribosome cytoplasm
septum digestion after cytokinesis endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) establishment of cell polarity maturation of SSU-rRNA maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosomal small subunit assembly
Molecular function:
mRNA binding
Cellular location:
small-subunit processome Pwp2p-containing subcomplex of 90S preribosome nucleolus nucleoplasm 90S preribosome cytoplasm
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 104 kDa | - |
Name: Utp6
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [2]
Biological process:
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
snoRNA binding
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
snoRNA binding
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 48 kDa | - |
Name: Utp12
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [12]
Biological process:
maturation of SSU-rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
U3 snoRNA binding snoRNA binding
Cellular location:
90S preribosome nucleoplasm small-subunit processome nucleolus Pwp2p-containing subcomplex of 90S preribosome
maturation of SSU-rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
U3 snoRNA binding snoRNA binding
Cellular location:
90S preribosome nucleoplasm small-subunit processome nucleolus Pwp2p-containing subcomplex of 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 105 kDa | - |
Name: Utp13
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 75 kDa | - |
Name: Utp18
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [10]
Biological process:
endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) RNA fragment catabolic process
Cellular location:
nucleoplasm small-subunit processome Pwp2p-containing subcomplex of 90S preribosome 90S preribosome nucleolus
endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) RNA fragment catabolic process
Cellular location:
nucleoplasm small-subunit processome Pwp2p-containing subcomplex of 90S preribosome 90S preribosome nucleolus
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 66 kDa | - |
Name: Utp21
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [8]
Biological process:
maturation of SSU-rRNA rRNA processing
Cellular location:
nucleus nucleolus 90S preribosome Pwp2p-containing subcomplex of 90S preribosome nucleoplasm small-subunit processome
maturation of SSU-rRNA rRNA processing
Cellular location:
nucleus nucleolus 90S preribosome Pwp2p-containing subcomplex of 90S preribosome nucleoplasm small-subunit processome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 104 kDa | - |
Name: Sof1
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [7]
Biological process:
maturation of SSU-rRNA maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
mRNA binding
Cellular location:
90S preribosome nucleolus small-subunit processome nucleoplasm
maturation of SSU-rRNA maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
mRNA binding
Cellular location:
90S preribosome nucleolus small-subunit processome nucleoplasm
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 56 kDa | - |
Name: Enp2
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [5]
Biological process:
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosomal small subunit biogenesis
Cellular location:
small-subunit processome 90S preribosome nucleolus
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosomal small subunit biogenesis
Cellular location:
small-subunit processome 90S preribosome nucleolus
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 81 kDa | - |
Name: Utp7
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [10]
Biological process:
endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular location:
90S preribosome nucleoplasm nucleolus preribosome, small subunit precursor small-subunit processome
endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular location:
90S preribosome nucleoplasm nucleolus preribosome, small subunit precursor small-subunit processome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 62 kDa | - |
Name: Kre33
EC number: 2.3.1.-
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
EC number: 2.3.1.-
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 95 kDa | - |
Name: Imp3
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [12]
Biological process:
maturation of SSU-rRNA rRNA processing ribosomal small subunit biogenesis
Molecular function:
structural constituent of ribosome rRNA binding snoRNA binding
Cellular location:
small ribosomal subunit Mpp10 complex nucleoplasm nucleolus small-subunit processome 90S preribosome
maturation of SSU-rRNA rRNA processing ribosomal small subunit biogenesis
Molecular function:
structural constituent of ribosome rRNA binding snoRNA binding
Cellular location:
small ribosomal subunit Mpp10 complex nucleoplasm nucleolus small-subunit processome 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 21 kDa | - |
Name: Mpp10
Number of copies: 1
UniProtKB UniProtKB PDBe-KB PDBe-KB PDBe-KB AlphaFold DB AlphaFold DB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB PDBe-KB PDBe-KB AlphaFold DB AlphaFold DB AlphaFold DB
Domains
Gene Ontology [12]
Biological process:
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA
Molecular function:
identical protein binding
Cellular location:
nucleoplasm small-subunit processome nucleolus nucleus sno(s)RNA-containing ribonucleoprotein complex Mpp10 complex 90S preribosome
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA
Molecular function:
identical protein binding
Cellular location:
nucleoplasm small-subunit processome nucleolus nucleus sno(s)RNA-containing ribonucleoprotein complex Mpp10 complex 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 67 kDa | - |
Name: Sas10
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [11]
Biological process:
endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cell cycle endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
identical protein binding
Cellular location:
nucleolus nucleoplasm nucleus small-subunit processome
endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cell cycle endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
identical protein binding
Cellular location:
nucleolus nucleoplasm nucleus small-subunit processome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 69 kDa | - |
Name: Lcp5
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [8]
Biological process:
maturation of SSU-rRNA endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular location:
sno(s)RNA-containing ribonucleoprotein complex small-subunit processome small nuclear ribonucleoprotein complex nucleolus
maturation of SSU-rRNA endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular location:
sno(s)RNA-containing ribonucleoprotein complex small-subunit processome small nuclear ribonucleoprotein complex nucleolus
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 40 kDa | - |
Name: Bud21
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [8]
Biological process:
endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA
Molecular function:
U3 snoRNA binding
Cellular location:
small-subunit processome 90S preribosome nucleolus
endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA
Molecular function:
U3 snoRNA binding
Cellular location:
small-subunit processome 90S preribosome nucleolus
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 23 kDa | - |
Name: Faf1
Number of copies: 1
UniProtKB UniProtKB PDBe-KB PDBe-KB AlphaFold DB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB PDBe-KB AlphaFold DB AlphaFold DB
Gene Ontology [4]
Biological process:
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular location:
nucleus cytoplasm nucleolus
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular location:
nucleus cytoplasm nucleolus
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 38 kDa | - |
Name: rpS13_uS15
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [9]
Biological process:
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cytoplasmic translation
Molecular function:
structural constituent of ribosome small ribosomal subunit rRNA binding
Cellular location:
cytosolic small ribosomal subunit cytosol 90S preribosome nucleolus cytoplasm
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cytoplasmic translation
Molecular function:
structural constituent of ribosome small ribosomal subunit rRNA binding
Cellular location:
cytosolic small ribosomal subunit cytosol 90S preribosome nucleolus cytoplasm
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 17 kDa | - |
Name: rpS14_uS11
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [12]
Biological process:
ribosomal small subunit assembly maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cytoplasmic translation translation
Molecular function:
structural constituent of ribosome mRNA binding
Cellular location:
cytosolic small ribosomal subunit nucleolus 90S preribosome nucleoplasm cytosol small-subunit processome
ribosomal small subunit assembly maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cytoplasmic translation translation
Molecular function:
structural constituent of ribosome mRNA binding
Cellular location:
cytosolic small ribosomal subunit nucleolus 90S preribosome nucleoplasm cytosol small-subunit processome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 14 kDa | - |
Name: Utp22
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [14]
Biological process:
tRNA export from nucleus maturation of SSU-rRNA regulation of ribosomal protein gene transcription by RNA polymerase II ribosomal small subunit assembly rRNA processing nucleolar large rRNA transcription by RNA polymerase I
Molecular function:
RNA binding
Cellular location:
nucleus CURI complex nucleolus nucleoplasm 90S preribosome small-subunit processome UTP-C complex
tRNA export from nucleus maturation of SSU-rRNA regulation of ribosomal protein gene transcription by RNA polymerase II ribosomal small subunit assembly rRNA processing nucleolar large rRNA transcription by RNA polymerase I
Molecular function:
RNA binding
Cellular location:
nucleus CURI complex nucleolus nucleoplasm 90S preribosome small-subunit processome UTP-C complex
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 140 kDa | - |
Name: Rrp7
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [12]
Biological process:
ribosomal small subunit assembly regulation of ribosomal protein gene transcription by RNA polymerase II nucleolar large rRNA transcription by RNA polymerase I maturation of SSU-rRNA rRNA processing
Molecular function:
rRNA binding
Cellular location:
nucleolus UTP-C complex CURI complex small-subunit processome nucleus nucleoplasm
ribosomal small subunit assembly regulation of ribosomal protein gene transcription by RNA polymerase II nucleolar large rRNA transcription by RNA polymerase I maturation of SSU-rRNA rRNA processing
Molecular function:
rRNA binding
Cellular location:
nucleolus UTP-C complex CURI complex small-subunit processome nucleus nucleoplasm
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 34 kDa | - |
Name: Rrp5
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [19]
Biological process:
rRNA processing maturation of SSU-rRNA 90S preribosome assembly endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
RNA binding poly(U) RNA binding box H/ACA snoRNA binding mRNA binding box C/D RNA binding rRNA primary transcript binding snoRNA binding U3 snoRNA binding
Cellular location:
small-subunit processome nucleoplasm 90S preribosome nucleolus
rRNA processing maturation of SSU-rRNA 90S preribosome assembly endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
RNA binding poly(U) RNA binding box H/ACA snoRNA binding mRNA binding box C/D RNA binding rRNA primary transcript binding snoRNA binding U3 snoRNA binding
Cellular location:
small-subunit processome nucleoplasm 90S preribosome nucleolus
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 193 kDa | - |
Name: Krr1
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB AlphaFold DB
Domains
Gene Ontology [4]
Biological process:
rRNA processing
Molecular function:
RNA binding
Cellular location:
ribonucleoprotein complex nucleolus
rRNA processing
Molecular function:
RNA binding
Cellular location:
ribonucleoprotein complex nucleolus
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 37 kDa | - |
Name: Nop56
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [13]
Biological process:
rRNA modification maturation of SSU-rRNA snoRNA guided rRNA 2'-O-methylation rRNA processing box C/D RNA 3'-end processing
Molecular function:
snoRNA binding mRNA binding
Cellular location:
nucleolus 90S preribosome small-subunit processome box C/D RNP complex nucleus nucleoplasm
rRNA modification maturation of SSU-rRNA snoRNA guided rRNA 2'-O-methylation rRNA processing box C/D RNA 3'-end processing
Molecular function:
snoRNA binding mRNA binding
Cellular location:
nucleolus 90S preribosome small-subunit processome box C/D RNP complex nucleus nucleoplasm
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 56 kDa | - |
Name: Nop58
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [3]
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 53 kDa | - |
Name: Nop1
EC number: 2.1.1.-
Number of copies: 2
UniProtKB UniProtKB PDBe-KB AlphaFold DB
EC number: 2.1.1.-
Number of copies: 2
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [20]
Biological process:
maturation of SSU-rRNA snoRNA guided rRNA 2'-O-methylation rRNA processing rRNA methylation box C/D RNA 3'-end processing sno(s)RNA processing regulation of transcription by RNA polymerase I histone glutamine methylation rRNA 2'-O-methylation
Molecular function:
histone H2AQ104 methyltransferase activity histone glutamine N-methyltransferase activity RNA binding O-methyltransferase activity rRNA methyltransferase activity histone-glutamine methyltransferase activity
Cellular location:
box C/D RNP complex small-subunit processome nucleolus 90S preribosome nucleoplasm
maturation of SSU-rRNA snoRNA guided rRNA 2'-O-methylation rRNA processing rRNA methylation box C/D RNA 3'-end processing sno(s)RNA processing regulation of transcription by RNA polymerase I histone glutamine methylation rRNA 2'-O-methylation
Molecular function:
histone H2AQ104 methyltransferase activity histone glutamine N-methyltransferase activity RNA binding O-methyltransferase activity rRNA methyltransferase activity histone-glutamine methyltransferase activity
Cellular location:
box C/D RNP complex small-subunit processome nucleolus 90S preribosome nucleoplasm
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 34 kDa | - |
Name: Snu13
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [22]
Biological process:
spliceosomal complex assembly maturation of SSU-rRNA mRNA splicing, via spliceosome maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) positive regulation of RNA binding box C/D RNA 3'-end processing maturation of LSU-rRNA snoRNA guided rRNA 2'-O-methylation
Molecular function:
RNA binding U4 snRNA binding U3 snoRNA binding
Cellular location:
nucleus U4/U6 snRNP spliceosomal complex U4 snRNP U4/U6 x U5 tri-snRNP complex nucleoplasm precatalytic spliceosome cytosolic large ribosomal subunit nucleolus box C/D RNP complex small-subunit processome
spliceosomal complex assembly maturation of SSU-rRNA mRNA splicing, via spliceosome maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) positive regulation of RNA binding box C/D RNA 3'-end processing maturation of LSU-rRNA snoRNA guided rRNA 2'-O-methylation
Molecular function:
RNA binding U4 snRNA binding U3 snoRNA binding
Cellular location:
nucleus U4/U6 snRNP spliceosomal complex U4 snRNP U4/U6 x U5 tri-snRNP complex nucleoplasm precatalytic spliceosome cytosolic large ribosomal subunit nucleolus box C/D RNP complex small-subunit processome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 13 kDa | - |
Name: Rrp9
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [11]
Biological process:
endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
U3 snoRNA binding snoRNA binding
Cellular location:
nucleoplasm nucleolus box C/D RNP complex small-subunit processome 90S preribosome
endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
U3 snoRNA binding snoRNA binding
Cellular location:
nucleoplasm nucleolus box C/D RNP complex small-subunit processome 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 65 kDa | - |
Name: Rcl1
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [14]
Biological process:
endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA processing ribosomal small subunit biogenesis regulation of rRNA processing maturation of SSU-rRNA
Molecular function:
enzyme activator activity RNA endonuclease activity
Cellular location:
small-subunit processome nucleolus 90S preribosome nucleoplasm
endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA processing ribosomal small subunit biogenesis regulation of rRNA processing maturation of SSU-rRNA
Molecular function:
enzyme activator activity RNA endonuclease activity
Cellular location:
small-subunit processome nucleolus 90S preribosome nucleoplasm
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 40 kDa | - |
Name: Bms1
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [4]
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 135 kDa | - |
Name: Emg1
EC number: 2.1.1.260
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
EC number: 2.1.1.260
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [19]
Biological process:
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA base methylation maturation of SSU-rRNA endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA methylation ribosomal small subunit biogenesis rRNA processing
Molecular function:
rRNA binding rRNA (pseudouridine) methyltransferase activity identical protein binding
Cellular location:
90S preribosome nuclear periphery cytoplasm nuclear microtubule nucleolus nucleoplasm nucleus small-subunit processome
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA base methylation maturation of SSU-rRNA endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA methylation ribosomal small subunit biogenesis rRNA processing
Molecular function:
rRNA binding rRNA (pseudouridine) methyltransferase activity identical protein binding
Cellular location:
90S preribosome nuclear periphery cytoplasm nuclear microtubule nucleolus nucleoplasm nucleus small-subunit processome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 27 kDa | - |
Name: Utp24
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [8]
Biological process:
maturation of SSU-rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
RNA endonuclease activity
Cellular location:
nucleoplasm small-subunit processome nucleolus
maturation of SSU-rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
RNA endonuclease activity
Cellular location:
nucleoplasm small-subunit processome nucleolus
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 21 kDa | - |
Name: Imp4
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [11]
Biological process:
maturation of SSU-rRNA ribosomal small subunit biogenesis rRNA processing
Molecular function:
rRNA primary transcript binding snoRNA binding single-stranded telomeric DNA binding
Cellular location:
nucleolus Mpp10 complex 90S preribosome nucleoplasm small-subunit processome
maturation of SSU-rRNA ribosomal small subunit biogenesis rRNA processing
Molecular function:
rRNA primary transcript binding snoRNA binding single-stranded telomeric DNA binding
Cellular location:
nucleolus Mpp10 complex 90S preribosome nucleoplasm small-subunit processome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 33 kDa | - |
Name: Utp30
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [10]
Biological process:
maturation of SSU-rRNA maturation of LSU-rRNA ribosomal small subunit biogenesis maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
RNA binding
Cellular location:
cytosolic large ribosomal subunit nucleus nucleolus small-subunit processome 90S preribosome
maturation of SSU-rRNA maturation of LSU-rRNA ribosomal small subunit biogenesis maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
RNA binding
Cellular location:
cytosolic large ribosomal subunit nucleus nucleolus small-subunit processome 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 31 kDa | - |
Name: Pno1
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [9]
Biological process:
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) proteasome assembly endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
unfolded protein binding RNA binding
Cellular location:
cytoplasm nucleolus nucleus 90S preribosome
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) proteasome assembly endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
unfolded protein binding RNA binding
Cellular location:
cytoplasm nucleolus nucleus 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 30 kDa | - |
Name: Utp20
Number of copies: 1
Number of copies: 1
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 83 kDa | - |
Name: Fcf2
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [6]
Biological process:
RNA processing endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular location:
nucleus nucleolus
RNA processing endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular location:
nucleus nucleolus
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 25 kDa | - |
Name: rpS23_uS12
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [3]
Biological process:
translation
Molecular function:
structural constituent of ribosome
Cellular location:
small ribosomal subunit
translation
Molecular function:
structural constituent of ribosome
Cellular location:
small ribosomal subunit
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 16 kDa | - |
Name: Utp14
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [8]
Biological process:
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
ATP binding
Cellular location:
nucleolus small-subunit processome nucleoplasm
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
ATP binding
Cellular location:
nucleolus small-subunit processome nucleoplasm
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 101 kDa | - |
Name: Nop14
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [17]
Biological process:
ribosomal small subunit biogenesis endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosomal small subunit assembly endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA
Molecular function:
U3 snoRNA binding
Cellular location:
preribosome, small subunit precursor 90S preribosome Noc4p-Nop14p complex nucleus nucleolus nucleoplasm small-subunit processome mitochondrion
ribosomal small subunit biogenesis endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosomal small subunit assembly endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA
Molecular function:
U3 snoRNA binding
Cellular location:
preribosome, small subunit precursor 90S preribosome Noc4p-Nop14p complex nucleus nucleolus nucleoplasm small-subunit processome mitochondrion
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 85 kDa | - |
Name: Noc4
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 58 kDa | - |
Name: Rrt14
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [1]
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 21 kDa | - |
Name: Unassigned peptides
Number of copies: 1
Number of copies: 1
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 8 kDa | - |
Name: Utp11
Number of copies: 1
UniProtKB AlphaFold DB
Number of copies: 1
UniProtKB AlphaFold DB
Domains
Gene Ontology [3]
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 29 kDa | - |
Name: Enp1
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [11]
Biological process:
rRNA processing poly(A)+ mRNA export from nucleus endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA
Molecular function:
snoRNA binding
Cellular location:
cytoplasm preribosome, small subunit precursor small-subunit processome 90S preribosome nucleus nucleolus
rRNA processing poly(A)+ mRNA export from nucleus endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA
Molecular function:
snoRNA binding
Cellular location:
cytoplasm preribosome, small subunit precursor small-subunit processome 90S preribosome nucleus nucleolus
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 55 kDa | - |