EMD-8678
Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle
EMD-8678
Single-particle8.3 Å
Deposition: 13/04/2017
Map released: 23/08/2017
Last modified: 13/03/2024
Name: Proteasome regulatory particle
Summary:
- Complex
- Protein
- 26S proteasome non-ATPase regulatory subunit 10
- 26S proteasome regulatory subunit 7
- 26S proteasome regulatory subunit 4
- 26S proteasome regulatory subunit 6B
- 26S proteasome regulatory subunit 10B
- 26S proteasome regulatory subunit 6A
- 26S proteasome regulatory subunit 8
- 26S proteasome non-ATPase regulatory subunit 2
Name:
26S proteasome non-ATPase regulatory subunit 10
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [29]
Biological process:
protein localization to plasma membrane regulation of transcription by RNA polymerase II negative regulation of NF-kappaB transcription factor activity positive regulation of protein ubiquitination apoptotic process negative regulation of transcription by RNA polymerase II negative regulation of apoptotic process cytoplasmic sequestering of NF-kappaB negative regulation of release of cytochrome c from mitochondria negative regulation of MAPK cascade positive regulation of cell growth positive regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of proteasomal ubiquitin-dependent protein catabolic process proteasome regulatory particle assembly
Molecular function:
RNA polymerase II-specific DNA-binding transcription factor binding cytoskeletal protein binding protein-macromolecule adaptor activity transmembrane transporter binding transcription factor binding
Cellular location:
plasma membrane cytoskeleton neuron projection intermediate filament cytoskeleton nucleoplasm cytoplasm cytosol proteasome complex nucleus
protein localization to plasma membrane regulation of transcription by RNA polymerase II negative regulation of NF-kappaB transcription factor activity positive regulation of protein ubiquitination apoptotic process negative regulation of transcription by RNA polymerase II negative regulation of apoptotic process cytoplasmic sequestering of NF-kappaB negative regulation of release of cytochrome c from mitochondria negative regulation of MAPK cascade positive regulation of cell growth positive regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of proteasomal ubiquitin-dependent protein catabolic process proteasome regulatory particle assembly
Molecular function:
RNA polymerase II-specific DNA-binding transcription factor binding cytoskeletal protein binding protein-macromolecule adaptor activity transmembrane transporter binding transcription factor binding
Cellular location:
plasma membrane cytoskeleton neuron projection intermediate filament cytoskeleton nucleoplasm cytoplasm cytosol proteasome complex nucleus
Natural source
Organism: Homo sapiens
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 24 kDa | - |
Recombinant Expression
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Homo sapiens | - | - | - |
26S proteasome regulatory subunit 7
Number of copies: 1
UniProtKB UniProtKB PDBe-KB PDBe-KB AlphaFold DB AlphaFold DB
Name: Number of copies: 1
UniProtKB UniProtKB PDBe-KB PDBe-KB AlphaFold DB AlphaFold DB
Domains
Gene Ontology [3]
Natural source
Organism: Homo sapiens
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 29 kDa | - |
Recombinant Expression
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Homo sapiens | - | - | - |
26S proteasome regulatory subunit 4
Number of copies: 1
UniProtKB UniProtKB PDBe-KB PDBe-KB AlphaFold DB AlphaFold DB
Name: Number of copies: 1
UniProtKB UniProtKB PDBe-KB PDBe-KB AlphaFold DB AlphaFold DB
Domains
Gene Ontology [3]
Natural source
Organism: Homo sapiens
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 29 kDa | - |
Recombinant Expression
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Homo sapiens | - | - | - |
26S proteasome regulatory subunit 6B
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [3]
Natural source
Organism: Homo sapiens
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 29 kDa | - |
Recombinant Expression
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Homo sapiens | - | - | - |
26S proteasome regulatory subunit 10B
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [5]
Biological process:
ubiquitin-dependent ERAD pathway
Molecular function:
proteasome-activating activity ATP binding ATP hydrolysis activity
Cellular location:
proteasome regulatory particle, base subcomplex
ubiquitin-dependent ERAD pathway
Molecular function:
proteasome-activating activity ATP binding ATP hydrolysis activity
Cellular location:
proteasome regulatory particle, base subcomplex
Natural source
Organism: Homo sapiens
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 29 kDa | - |
Recombinant Expression
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Homo sapiens | - | - | - |
26S proteasome regulatory subunit 6A
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [3]
Natural source
Organism: Homo sapiens
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 29 kDa | - |
Recombinant Expression
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Homo sapiens | - | - | - |
26S proteasome regulatory subunit 8
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Molecular function:
ATP hydrolysis activity ATP binding proteasome-activating activity
Cellular location:
cytoplasm
Name: Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [4]
Molecular function:
ATP hydrolysis activity ATP binding proteasome-activating activity
Cellular location:
cytoplasm
Natural source
Organism: Homo sapiens
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 29 kDa | - |
Recombinant Expression
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Homo sapiens | - | - | - |
26S proteasome non-ATPase regulatory subunit 2
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [16]
Biological process:
proteasome-mediated ubiquitin-dependent protein catabolic process regulation of protein catabolic process
Molecular function:
enzyme regulator activity
Cellular location:
extracellular region cytosol proteasome regulatory particle proteasome storage granule proteasome accessory complex extracellular exosome secretory granule lumen membrane ficolin-1-rich granule lumen nucleus proteasome regulatory particle, base subcomplex nucleoplasm proteasome complex
proteasome-mediated ubiquitin-dependent protein catabolic process regulation of protein catabolic process
Molecular function:
enzyme regulator activity
Cellular location:
extracellular region cytosol proteasome regulatory particle proteasome storage granule proteasome accessory complex extracellular exosome secretory granule lumen membrane ficolin-1-rich granule lumen nucleus proteasome regulatory particle, base subcomplex nucleoplasm proteasome complex
Natural source
Organism: Homo sapiens
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 93 kDa | - |
Recombinant Expression
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Homo sapiens | - | - | - |