EMD-8560 Function and Biology

Cryo-EM structure of bovine multidrug resistance protein 1 (MRP1) bound to leukotriene C4

Single particle reconstruction
3.34Å resolution
Overview of EMD-8560
Sample name: bovine multidrug resistance protein 1 (MRP1) complexed with leukotriene C4
Number of unique components: 3

bovine multidrug resistance protein 1 (MRP1) complexed with leukotriene C4 [Bos taurus]

Protein type
Name: bovine multidrug resistance protein 1 (MRP1) complexed with leukotriene C4
Theoretical weight (MDa): 0.17
Expression system
Expression system: Homo sapiens
Cell line: HEK293S GntI-
Vector: Baculovirus

bovine multidrug resistance protein 1 (MRP1),Multidrug resistance-associated protein 1 [Bos taurus]

Protein type
Name: bovine multidrug resistance protein 1 (MRP1),Multidrug resistance-associated protein 1
Theoretical weight (MDa): 0.16
Number of copies: 1
Expression system
Expression system: Homo sapiens

(5~{S},6~{R},7~{E},9~{E},11~{Z},14~{Z})-6-[(2~{R})-2-[[(4~{S})-4-azanyl-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]-3-(2-hydroxy-2-oxoethylamino)-3-oxidanylidene-propyl]sulfanyl-5-oxidanyl-icosa-7,9,11,14-tetraenoic acid

Ligand type
Name: (5~{S},6~{R},7~{E},9~{E},11~{Z},14~{Z})-6-[(2~{R})-2-[[(4~{S})-4-azanyl-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]-3-(2-hydroxy-2-oxoethylamino)-3-oxidanylidene-propyl]sulfanyl-5-oxidanyl-icosa-7,9,11,14-tetraenoic acid
Theoretical weight (MDa): 0.001
Number of copies: 1