EMD-8461
Structure of the cystic fibrosis transmembrane conductance regulator (CFTR) from zebrafish
EMD-8461
Single-particle3.73 Å
Deposition: 28/10/2016
Map released: 07/12/2016
Last modified: 12/09/2018
Name: Cystic fibrosis transmembrane conductance regulator or ABCC7
Summary:
Cystic fibrosis transmembrane conductance regulator or ABCC7
Name: Natural source [1]
Organism: Danio rerio
Recombinant Expression [1]
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Homo sapiens | - | HEK 293S GnTI- | pEG Bacmam |
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
168.0 kDa/nm | - | - |
Cystic fibrosis transmembrane conductance regulator
EC number: 3.6.3.49
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Name: EC number: 3.6.3.49
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [37]
Biological process:
T cell differentiation lymphoid lineage cell migration into thymus Spemann organizer formation at the embryonic shield heart development innate immune response multicellular organismal-level water homeostasis transepithelial water transport germ cell migration cellular response to forskolin bicarbonate transport regulation of neutrophil chemotaxis chloride transmembrane transport Kupffer's vesicle development pancreas development transmembrane transport embryonic hemopoiesis defense response to bacterium respiratory burst involved in defense response multicellular organismal water homeostasis
Molecular function:
ATP hydrolysis activity chloride channel activity intracellularly ATP-gated chloride channel activity ABC-type transporter activity isomerase activity bicarbonate transmembrane transporter activity ATPase-coupled transmembrane transporter activity ATP binding
Cellular location:
apical plasma membrane integral component of membrane early endosome membrane endoplasmic reticulum membrane cytosol plasma membrane integral component of plasma membrane membrane recycling endosome membrane chloride channel complex
T cell differentiation lymphoid lineage cell migration into thymus Spemann organizer formation at the embryonic shield heart development innate immune response multicellular organismal-level water homeostasis transepithelial water transport germ cell migration cellular response to forskolin bicarbonate transport regulation of neutrophil chemotaxis chloride transmembrane transport Kupffer's vesicle development pancreas development transmembrane transport embryonic hemopoiesis defense response to bacterium respiratory burst involved in defense response multicellular organismal water homeostasis
Molecular function:
ATP hydrolysis activity chloride channel activity intracellularly ATP-gated chloride channel activity ABC-type transporter activity isomerase activity bicarbonate transmembrane transporter activity ATPase-coupled transmembrane transporter activity ATP binding
Cellular location:
apical plasma membrane integral component of membrane early endosome membrane endoplasmic reticulum membrane cytosol plasma membrane integral component of plasma membrane membrane recycling endosome membrane chloride channel complex
Natural source
Organism: Danio rerio
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 169 kDa | - |
Recombinant Expression
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Homo sapiens | - | - | - |