EMD-7442
Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from Homo sapiens
EMD-7442
Single-particle2.8 Å
Deposition: 31/01/2018
Map released: 11/04/2018
Last modified: 25/11/2020
Name: Translation initiation factor eIF-2B decamer
Summary:
Translation initiation factor eIF-2B decamer
Name: Natural source [1]
Organism: Homo sapiens
Recombinant Expression [1]
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Escherichia coli | - | - | - |
Complex Portal [1]
ID | Name | Overlap |
---|---|---|
CPX-8343 | Eukaryotic translation initiation factor 2B complex | 1.00 |
Translation initiation factor eIF-2B subunit epsilon
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [24]
Biological process:
cytoplasmic translational initiation hippocampus development T cell receptor signaling pathway response to lithium ion astrocyte differentiation response to heat response to peptide hormone myelination response to endoplasmic reticulum stress positive regulation of apoptotic process ovarian follicle development response to glucose astrocyte development aging oligodendrocyte development translational initiation positive regulation of translational initiation
Molecular function:
translation initiation factor binding guanyl-nucleotide exchange factor activity translation initiation factor activity
Cellular location:
cytoplasm eukaryotic translation initiation factor 2B complex cytosol nucleus
cytoplasmic translational initiation hippocampus development T cell receptor signaling pathway response to lithium ion astrocyte differentiation response to heat response to peptide hormone myelination response to endoplasmic reticulum stress positive regulation of apoptotic process ovarian follicle development response to glucose astrocyte development aging oligodendrocyte development translational initiation positive regulation of translational initiation
Molecular function:
translation initiation factor binding guanyl-nucleotide exchange factor activity translation initiation factor activity
Cellular location:
cytoplasm eukaryotic translation initiation factor 2B complex cytosol nucleus
Natural source
Organism: Homo sapiens
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 80 kDa | - |
Recombinant Expression
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Escherichia coli | - | - | - |
Translation initiation factor eIF-2B subunit gamma
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [14]
Biological process:
response to heat response to glucose regulation of catalytic activity T cell receptor signaling pathway cytoplasmic translational initiation oligodendrocyte development translational initiation response to peptide hormone
Molecular function:
guanyl-nucleotide exchange factor activity translation initiation factor activity
Cellular location:
cytosol eukaryotic translation initiation factor 2B complex cytoplasm guanyl-nucleotide exchange factor complex
response to heat response to glucose regulation of catalytic activity T cell receptor signaling pathway cytoplasmic translational initiation oligodendrocyte development translational initiation response to peptide hormone
Molecular function:
guanyl-nucleotide exchange factor activity translation initiation factor activity
Cellular location:
cytosol eukaryotic translation initiation factor 2B complex cytoplasm guanyl-nucleotide exchange factor complex
Natural source
Organism: Homo sapiens
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 50 kDa | - |
Recombinant Expression
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Escherichia coli | - | - | - |
Translation initiation factor eIF-2B subunit alpha
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [16]
Biological process:
cytoplasmic translational initiation regulation of catalytic activity response to glucose T cell receptor signaling pathway response to peptide hormone translational initiation oligodendrocyte development response to heat
Molecular function:
guanyl-nucleotide exchange factor activity translation initiation factor activity identical protein binding
Cellular location:
membrane cytosol eukaryotic translation initiation factor 2B complex plasma membrane cytoplasm
cytoplasmic translational initiation regulation of catalytic activity response to glucose T cell receptor signaling pathway response to peptide hormone translational initiation oligodendrocyte development response to heat
Molecular function:
guanyl-nucleotide exchange factor activity translation initiation factor activity identical protein binding
Cellular location:
membrane cytosol eukaryotic translation initiation factor 2B complex plasma membrane cytoplasm
Natural source
Organism: Homo sapiens
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 33 kDa | - |
Recombinant Expression
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Escherichia coli | - | - | - |
Translation initiation factor eIF-2B subunit beta
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [19]
Biological process:
cytoplasmic translational initiation myelination translational initiation response to heat T cell receptor signaling pathway regulation of translational initiation oligodendrocyte development central nervous system development response to peptide hormone ovarian follicle development regulation of catalytic activity response to glucose
Molecular function:
guanyl-nucleotide exchange factor activity ATP binding translation initiation factor activity GTP binding
Cellular location:
eukaryotic translation initiation factor 2B complex cytosol cytoplasm
cytoplasmic translational initiation myelination translational initiation response to heat T cell receptor signaling pathway regulation of translational initiation oligodendrocyte development central nervous system development response to peptide hormone ovarian follicle development regulation of catalytic activity response to glucose
Molecular function:
guanyl-nucleotide exchange factor activity ATP binding translation initiation factor activity GTP binding
Cellular location:
eukaryotic translation initiation factor 2B complex cytosol cytoplasm
Natural source
Organism: Homo sapiens
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 41 kDa | - |
Recombinant Expression
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Escherichia coli | - | - | - |
Translation initiation factor eIF-2B subunit delta
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [17]
Biological process:
cytoplasmic translational initiation response to peptide hormone T cell receptor signaling pathway regulation of catalytic activity translational initiation myelination regulation of translation response to heat oligodendrocyte development response to glucose ovarian follicle development
Molecular function:
guanyl-nucleotide exchange factor activity translation initiation factor activity translation initiation factor binding
Cellular location:
cytoplasm eukaryotic translation initiation factor 2B complex cytosol
cytoplasmic translational initiation response to peptide hormone T cell receptor signaling pathway regulation of catalytic activity translational initiation myelination regulation of translation response to heat oligodendrocyte development response to glucose ovarian follicle development
Molecular function:
guanyl-nucleotide exchange factor activity translation initiation factor activity translation initiation factor binding
Cellular location:
cytoplasm eukaryotic translation initiation factor 2B complex cytosol
Natural source
Organism: Homo sapiens
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 57 kDa | - |
Recombinant Expression
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Escherichia coli | - | - | - |
2-(4-chloranylphenoxy)-~{N}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide
HET code: C7B
Number of copies: 1
ChEMBL
Name: HET code: C7B
Number of copies: 1
ChEMBL
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 451 Da | - |