EMD-4785
D. melanogaster CMG-DNA with ATP, State 1A
EMD-4785
Single-particle3.7 Å
Deposition: 08/04/2019
Map released: 11/09/2019
Last modified: 02/12/2020
Name: CMG helicase bound to forked DNA in the presence of ATP, State 1A
Summary:
- Complex
- Protein
- DNA replication licensing factor Mcm2
- DNA replication licensing factor Mcm3
- DNA replication licensing factor MCM4
- DNA replication licensing factor Mcm5
- DNA replication licensing factor Mcm6
- DNA replication licensing factor Mcm7
- CDC45L
- IP07275p
- Probable DNA replication complex GINS protein PSF2
- AT18545p
- DNA replication complex GINS protein SLD5
- DNA
- Ligand
CMG helicase bound to forked DNA in the presence of ATP, State 1A
Name: Complex Portal [1]
ID | Name | Overlap |
---|---|---|
CPX-2942 | MCM complex | 0.67 |
CMG helicase
Name: Natural source [1]
Organism: Drosophila melanogaster
Recombinant Expression [1]
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Trichoplusia ni | - | - | - |
Complex Portal [1]
ID | Name | Overlap |
---|---|---|
CPX-2942 | MCM complex | 0.67 |
DNA
Name: Natural source [1]
Organism: Drosophila melanogaster
Recombinant Expression [1]
Organism | Strain | Cell | Plasmid |
---|---|---|---|
synthetic construct | - | - | - |
DNA replication licensing factor Mcm2
EC number: 3.6.4.12
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Name: EC number: 3.6.4.12
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [20]
Biological process:
premeiotic DNA replication regulation of DNA-templated DNA replication initiation regulation of DNA-dependent DNA replication initiation negative regulation of DNA helicase activity DNA unwinding involved in DNA replication cell division double-strand break repair via break-induced replication chromosome condensation mitotic DNA replication initiation DNA replication
Molecular function:
helicase activity hydrolase activity single-stranded DNA binding DNA helicase activity ATP hydrolysis activity metal ion binding ATP binding
Cellular location:
CMG complex MCM complex nucleus
premeiotic DNA replication regulation of DNA-templated DNA replication initiation regulation of DNA-dependent DNA replication initiation negative regulation of DNA helicase activity DNA unwinding involved in DNA replication cell division double-strand break repair via break-induced replication chromosome condensation mitotic DNA replication initiation DNA replication
Molecular function:
helicase activity hydrolase activity single-stranded DNA binding DNA helicase activity ATP hydrolysis activity metal ion binding ATP binding
Cellular location:
CMG complex MCM complex nucleus
Natural source
Organism: Drosophila melanogaster
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 100 kDa | - |
Recombinant Expression
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Trichoplusia ni | - | - | - |
DNA replication licensing factor Mcm3
EC number: 3.6.4.12
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Name: EC number: 3.6.4.12
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [15]
Biological process:
premeiotic DNA replication DNA duplex unwinding regulation of DNA-templated DNA replication initiation regulation of DNA-dependent DNA replication initiation mitotic DNA replication initiation double-strand break repair via break-induced replication DNA strand elongation involved in DNA replication
Molecular function:
helicase activity ATP binding DNA helicase activity ATP hydrolysis activity single-stranded DNA binding
Cellular location:
nucleus MCM complex CMG complex
premeiotic DNA replication DNA duplex unwinding regulation of DNA-templated DNA replication initiation regulation of DNA-dependent DNA replication initiation mitotic DNA replication initiation double-strand break repair via break-induced replication DNA strand elongation involved in DNA replication
Molecular function:
helicase activity ATP binding DNA helicase activity ATP hydrolysis activity single-stranded DNA binding
Cellular location:
nucleus MCM complex CMG complex
Natural source
Organism: Drosophila melanogaster
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 91 kDa | - |
Recombinant Expression
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Trichoplusia ni | - | - | - |
DNA replication licensing factor MCM4
EC number: 3.6.4.12
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Name: EC number: 3.6.4.12
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [16]
Biological process:
premeiotic DNA replication regulation of DNA-templated DNA replication initiation regulation of DNA-dependent DNA replication initiation DNA unwinding involved in DNA replication DNA strand elongation involved in DNA replication mitotic spindle organization mitotic DNA replication initiation double-strand break repair via break-induced replication DNA replication
Molecular function:
DNA helicase activity single-stranded DNA binding ATP hydrolysis activity ATP binding
Cellular location:
CMG complex nucleus MCM complex
premeiotic DNA replication regulation of DNA-templated DNA replication initiation regulation of DNA-dependent DNA replication initiation DNA unwinding involved in DNA replication DNA strand elongation involved in DNA replication mitotic spindle organization mitotic DNA replication initiation double-strand break repair via break-induced replication DNA replication
Molecular function:
DNA helicase activity single-stranded DNA binding ATP hydrolysis activity ATP binding
Cellular location:
CMG complex nucleus MCM complex
Natural source
Organism: Drosophila melanogaster
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 96 kDa | - |
Recombinant Expression
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Trichoplusia ni | - | - | - |
DNA replication licensing factor Mcm5
EC number: 3.6.4.12
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Name: EC number: 3.6.4.12
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [20]
Biological process:
premeiotic DNA replication DNA duplex unwinding regulation of DNA-templated DNA replication initiation regulation of DNA-dependent DNA replication initiation meiotic cell cycle chromosome condensation DNA replication initiation double-strand break repair via break-induced replication resolution of meiotic recombination intermediates DNA endoreduplication
Molecular function:
helicase activity single-stranded DNA binding DNA replication origin binding ATP hydrolysis activity ATP binding DNA helicase activity
Cellular location:
cytosol MCM complex nucleus CMG complex
premeiotic DNA replication DNA duplex unwinding regulation of DNA-templated DNA replication initiation regulation of DNA-dependent DNA replication initiation meiotic cell cycle chromosome condensation DNA replication initiation double-strand break repair via break-induced replication resolution of meiotic recombination intermediates DNA endoreduplication
Molecular function:
helicase activity single-stranded DNA binding DNA replication origin binding ATP hydrolysis activity ATP binding DNA helicase activity
Cellular location:
cytosol MCM complex nucleus CMG complex
Natural source
Organism: Drosophila melanogaster
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 82 kDa | - |
Recombinant Expression
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Trichoplusia ni | - | - | - |
DNA replication licensing factor Mcm6
EC number: 3.6.4.12
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Name: EC number: 3.6.4.12
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [18]
Biological process:
premeiotic DNA replication regulation of DNA-templated DNA replication initiation regulation of DNA-dependent DNA replication initiation eggshell chorion gene amplification mitotic DNA replication DNA replication initiation DNA replication DNA unwinding involved in DNA replication double-strand break repair via break-induced replication cell division
Molecular function:
ATP hydrolysis activity DNA helicase activity single-stranded DNA binding ATP binding metal ion binding
Cellular location:
nucleus MCM complex CMG complex
premeiotic DNA replication regulation of DNA-templated DNA replication initiation regulation of DNA-dependent DNA replication initiation eggshell chorion gene amplification mitotic DNA replication DNA replication initiation DNA replication DNA unwinding involved in DNA replication double-strand break repair via break-induced replication cell division
Molecular function:
ATP hydrolysis activity DNA helicase activity single-stranded DNA binding ATP binding metal ion binding
Cellular location:
nucleus MCM complex CMG complex
Natural source
Organism: Drosophila melanogaster
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 92 kDa | - |
Recombinant Expression
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Trichoplusia ni | - | - | - |
DNA replication licensing factor Mcm7
EC number: 3.6.4.12
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Name: EC number: 3.6.4.12
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [15]
Biological process:
premeiotic DNA replication regulation of DNA-templated DNA replication initiation regulation of DNA-dependent DNA replication initiation double-strand break repair via break-induced replication cell cycle DNA strand elongation involved in DNA replication DNA replication initiation DNA unwinding involved in DNA replication
Molecular function:
ATP binding DNA helicase activity single-stranded DNA binding ATP hydrolysis activity
Cellular location:
MCM complex nucleus CMG complex
premeiotic DNA replication regulation of DNA-templated DNA replication initiation regulation of DNA-dependent DNA replication initiation double-strand break repair via break-induced replication cell cycle DNA strand elongation involved in DNA replication DNA replication initiation DNA unwinding involved in DNA replication
Molecular function:
ATP binding DNA helicase activity single-stranded DNA binding ATP hydrolysis activity
Cellular location:
MCM complex nucleus CMG complex
Natural source
Organism: Drosophila melanogaster
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 81 kDa | - |
Recombinant Expression
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Trichoplusia ni | - | - | - |
CDC45L
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [14]
Biological process:
mitotic DNA replication preinitiation complex assembly chromosome condensation DNA replication initiation DNA replication cell division double-strand break repair via break-induced replication DNA amplification
Molecular function:
DNA replication origin binding single-stranded DNA binding chromatin binding
Cellular location:
nucleus CMG complex cytoplasm DNA replication preinitiation complex
mitotic DNA replication preinitiation complex assembly chromosome condensation DNA replication initiation DNA replication cell division double-strand break repair via break-induced replication DNA amplification
Molecular function:
DNA replication origin binding single-stranded DNA binding chromatin binding
Cellular location:
nucleus CMG complex cytoplasm DNA replication preinitiation complex
Natural source
Organism: Drosophila melanogaster
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 65 kDa | - |
Recombinant Expression
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Trichoplusia ni | - | - | - |
IP07275p
Number of copies: 1
Name: Number of copies: 1
Natural source
Organism: Drosophila melanogaster
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 23 kDa | - |
Recombinant Expression
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Trichoplusia ni | - | - | - |
Probable DNA replication complex GINS protein PSF2
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [9]
Biological process:
regulation of DNA-templated transcription elongation regulation of DNA-templated transcription, elongation chromosome condensation DNA strand elongation involved in DNA replication double-strand break repair via break-induced replication DNA replication initiation
Cellular location:
nucleus CMG complex GINS complex
regulation of DNA-templated transcription elongation regulation of DNA-templated transcription, elongation chromosome condensation DNA strand elongation involved in DNA replication double-strand break repair via break-induced replication DNA replication initiation
Cellular location:
nucleus CMG complex GINS complex
Natural source
Organism: Drosophila melanogaster
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 23 kDa | - |
Recombinant Expression
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Trichoplusia ni | - | - | - |
AT18545p
Number of copies: 1
Name: Number of copies: 1
Natural source
Organism: Drosophila melanogaster
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 24 kDa | - |
Recombinant Expression
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Trichoplusia ni | - | - | - |
DNA replication complex GINS protein SLD5
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [5]
Biological process:
double-strand break repair via break-induced replication DNA replication initiation mitotic cell cycle
Cellular location:
CMG complex GINS complex
double-strand break repair via break-induced replication DNA replication initiation mitotic cell cycle
Cellular location:
CMG complex GINS complex
Natural source
Organism: Drosophila melanogaster
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 26 kDa | - |
Recombinant Expression
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Trichoplusia ni | - | - | - |
DNA
Number of copies: 1
Name: Number of copies: 1
Natural source
Organism: Drosophila melanogaster
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 7 kDa | - |
DNA (5'-D(P*TP*CP*GP*AP*TP*CP*GP*AP*TP*CP*GP*AP*T)-3')
Number of copies: 1
Name: Number of copies: 1
Natural source
Organism: Drosophila melanogaster
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 3 kDa | - |
ADENOSINE-5'-TRIPHOSPHATE
HET code: ATP
Number of copies: 3
ChEMBL ChEBI DrugBank
Name: HET code: ATP
Number of copies: 3
ChEMBL ChEBI DrugBank
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 507 Da | - |
ADENOSINE-5'-DIPHOSPHATE
HET code: ADP
Number of copies: 3
ChEMBL ChEBI DrugBank
Name: HET code: ADP
Number of copies: 3
ChEMBL ChEBI DrugBank
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 427 Da | - |