EMD-4631

Single-particle
24.8 Å
EMD-4631
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Deposition: 22/02/2019
Map released: 25/03/2020
Last modified: 25/11/2020
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EMD-4631
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A dimer component of alpha-1 antitrypsin polymers isolated from ZZ explant liver tissue and decorated with Fab 4B12 (component B with ~90 degree rotation around the dimer axis)

EMD-4631

Single-particle
24.8 Å
EMD-4631
3D View Gallery
Deposition: 22/02/2019
Map released: 25/03/2020
Last modified: 25/11/2020
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Name: Polymers of the severe deficiency Z variant of alpha-1 antitrypsin labelled with 4B12 Fab fragments
Tissue [1]
Name: Polymers of the severe deficiency Z variant of alpha-1 antitrypsin labelled with 4B12 Fab fragments
Details: Polymers of alpha-1 antitrypsin were isolated from patient explant tissue and labelled with the Fab fragment of a non-conformationally selective monoclonal antibody (4B12).
Natural source [1]
Organism: Homo sapiens
Organ: Liver
Tissue: Explant tissue
Complex [1]
Name: Complex between two 4B12 Fab fragments and a dimer component of polymers of the severe deficiency Z alpha-1 antitrypsin variant
Natural source [1]
Organism: Homo sapiens
Molecular weight
Experimental Theoretical Method
200 kDa - -
Protein [3]
LEVO
Name: Alpha-1 antitrypsin
Details: 'Z' severe deficiency variant of alpha-1 antitrypsin
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Homo sapiens
Organ: Liver
Tissue: Explant tissue
LEVO
Name: 4B12 Fab heavy chain
Details: Heavy chain of the Fab fragment of a non-conformationally-selective antibody (4B12) that binds to alpha-1-antitrypsin
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Mus musculus
Strain: BALB/c
Organ: Spleen
LEVO
Name: 4B12 Fab light chain
Details: Light chain of the Fab fragment of a non-conformationally-selective antibody (4B12) that binds to alpha-1-antitrypsin
Natural source
Organism: Mus musculus
Strain: BALB/c
Organ: Spleen