EMD-4321
26S proteasome, s3 state
EMD-4321
Single-particle5.4 Å
Deposition: 05/03/2018
Map released: 22/08/2018
Last modified: 24/10/2018
Name: 26S proteasome
Summary:
- Complex
- Protein
- Proteasome subunit alpha type-1
- Proteasome subunit alpha type-2
- Proteasome subunit alpha type-3
- Proteasome subunit alpha type-4
- Proteasome subunit alpha type-5
- Proteasome subunit alpha type-6
- Probable proteasome subunit alpha type-7
- Proteasome subunit beta type-1
- Proteasome subunit beta type-2
- Proteasome subunit beta type-3
- Proteasome subunit beta type-4
- Proteasome subunit beta type-5
- Proteasome subunit beta type-6
- Proteasome subunit beta type-7
- 26S proteasome regulatory subunit RPN10
- Ubiquitin carboxyl-terminal hydrolase RPN11
- 26S proteasome regulatory subunit RPN12
- 26S proteasome regulatory subunit RPN13
- 26S proteasome complex subunit SEM1
- 26S proteasome regulatory subunit RPN1
- 26S proteasome regulatory subunit RPN2
- 26S proteasome regulatory subunit RPN3
- 26S proteasome regulatory subunit RPN5
- 26S proteasome regulatory subunit RPN6
- 26S proteasome regulatory subunit RPN7
- 26S proteasome regulatory subunit RPN8
- 26S proteasome regulatory subunit RPN9
- 26S proteasome regulatory subunit 7 homolog
- 26S proteasome regulatory subunit 4 homolog
- 26S proteasome regulatory subunit 6B homolog
- 26S proteasome subunit RPT4
- 26S proteasome regulatory subunit 6A
- 26S proteasome regulatory subunit 8 homolog
- Ligand
26S proteasome
Name: Natural source [1]
Complex Portal [1]
ID | Name | Overlap |
---|---|---|
CPX-2262 | 26S Proteasome complex | 0.91 |
Proteasome subunit alpha type-1
EC number: 3.4.25.1
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Name: EC number: 3.4.25.1
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 27 kDa | - |
Proteasome subunit alpha type-2
EC number: 3.4.25.1
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Name: EC number: 3.4.25.1
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [10]
Biological process:
proteasomal ubiquitin-independent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process proteasomal protein catabolic process
Cellular location:
proteasome complex cytoplasm nuclear outer membrane-endoplasmic reticulum membrane network proteasome storage granule proteasome core complex, alpha-subunit complex proteasome core complex nucleus
proteasomal ubiquitin-independent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process proteasomal protein catabolic process
Cellular location:
proteasome complex cytoplasm nuclear outer membrane-endoplasmic reticulum membrane network proteasome storage granule proteasome core complex, alpha-subunit complex proteasome core complex nucleus
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 27 kDa | - |
Proteasome subunit alpha type-3
EC number: 3.4.25.1
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Name: EC number: 3.4.25.1
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [12]
Biological process:
proteasome-mediated ubiquitin-dependent protein catabolic process proteasomal ubiquitin-independent protein catabolic process proteasome core complex assembly proteasomal protein catabolic process
Molecular function:
threonine-type endopeptidase activity
Cellular location:
nuclear outer membrane-endoplasmic reticulum membrane network cytosol proteasome complex proteasome core complex, alpha-subunit complex proteasome core complex proteasome storage granule nucleus
proteasome-mediated ubiquitin-dependent protein catabolic process proteasomal ubiquitin-independent protein catabolic process proteasome core complex assembly proteasomal protein catabolic process
Molecular function:
threonine-type endopeptidase activity
Cellular location:
nuclear outer membrane-endoplasmic reticulum membrane network cytosol proteasome complex proteasome core complex, alpha-subunit complex proteasome core complex proteasome storage granule nucleus
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 27 kDa | - |
Proteasome subunit alpha type-4
EC number: 3.4.25.1
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Name: EC number: 3.4.25.1
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [11]
Biological process:
proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process proteasomal ubiquitin-independent protein catabolic process
Molecular function:
threonine-type endopeptidase activity
Cellular location:
proteasome core complex proteasome core complex, alpha-subunit complex proteasome complex proteasome storage granule nuclear outer membrane-endoplasmic reticulum membrane network nucleus mitochondrion
proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process proteasomal ubiquitin-independent protein catabolic process
Molecular function:
threonine-type endopeptidase activity
Cellular location:
proteasome core complex proteasome core complex, alpha-subunit complex proteasome complex proteasome storage granule nuclear outer membrane-endoplasmic reticulum membrane network nucleus mitochondrion
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 28 kDa | - |
Proteasome subunit alpha type-5
EC number: 3.4.25.1
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Name: EC number: 3.4.25.1
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [10]
Biological process:
proteasome-mediated ubiquitin-dependent protein catabolic process proteasomal protein catabolic process proteasomal ubiquitin-independent protein catabolic process
Cellular location:
proteasome core complex, alpha-subunit complex nuclear outer membrane-endoplasmic reticulum membrane network proteasome complex proteasome core complex nucleus cytoplasm proteasome storage granule
proteasome-mediated ubiquitin-dependent protein catabolic process proteasomal protein catabolic process proteasomal ubiquitin-independent protein catabolic process
Cellular location:
proteasome core complex, alpha-subunit complex nuclear outer membrane-endoplasmic reticulum membrane network proteasome complex proteasome core complex nucleus cytoplasm proteasome storage granule
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 26 kDa | - |
Proteasome subunit alpha type-6
EC number: 3.4.25.1
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Name: EC number: 3.4.25.1
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [10]
Biological process:
proteasome-mediated ubiquitin-dependent protein catabolic process proteasomal protein catabolic process proteasomal ubiquitin-independent protein catabolic process
Cellular location:
proteasome complex proteasome core complex, alpha-subunit complex proteasome storage granule cytoplasm proteasome core complex nucleus nuclear outer membrane-endoplasmic reticulum membrane network
proteasome-mediated ubiquitin-dependent protein catabolic process proteasomal protein catabolic process proteasomal ubiquitin-independent protein catabolic process
Cellular location:
proteasome complex proteasome core complex, alpha-subunit complex proteasome storage granule cytoplasm proteasome core complex nucleus nuclear outer membrane-endoplasmic reticulum membrane network
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 25 kDa | - |
Probable proteasome subunit alpha type-7
EC number: 3.4.25.1
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Name: EC number: 3.4.25.1
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [2]
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 26 kDa | - |
Proteasome subunit beta type-1
EC number: 3.4.25.1
Number of copies: 2
UniProtKB PDBe-KB PDBe-KB AlphaFold DB AlphaFold DB
Name: EC number: 3.4.25.1
Number of copies: 2
UniProtKB PDBe-KB PDBe-KB AlphaFold DB AlphaFold DB
Domains
Gene Ontology [11]
Biological process:
proteasomal protein catabolic process proteasomal ubiquitin-independent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process
Molecular function:
endopeptidase activity threonine-type endopeptidase activity
Cellular location:
proteasome storage granule proteasome complex proteasome core complex proteasome core complex, beta-subunit complex endoplasmic reticulum membrane nucleus
proteasomal protein catabolic process proteasomal ubiquitin-independent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process
Molecular function:
endopeptidase activity threonine-type endopeptidase activity
Cellular location:
proteasome storage granule proteasome complex proteasome core complex proteasome core complex, beta-subunit complex endoplasmic reticulum membrane nucleus
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 21 kDa | - |
Proteasome subunit beta type-2
EC number: 3.4.25.1
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Molecular function:
threonine-type endopeptidase activity
Cellular location:
proteasome core complex
Name: EC number: 3.4.25.1
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [2]
Molecular function:
threonine-type endopeptidase activity
Cellular location:
proteasome core complex
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 24 kDa | - |
Proteasome subunit beta type-3
EC number: 3.4.25.1
Number of copies: 2
UniProtKB PDBe-KB PDBe-KB AlphaFold DB AlphaFold DB
Name: EC number: 3.4.25.1
Number of copies: 2
UniProtKB PDBe-KB PDBe-KB AlphaFold DB AlphaFold DB
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 22 kDa | - |
Proteasome subunit beta type-4
EC number: 3.4.25.1
Number of copies: 2
UniProtKB PDBe-KB PDBe-KB AlphaFold DB AlphaFold DB
Name: EC number: 3.4.25.1
Number of copies: 2
UniProtKB PDBe-KB PDBe-KB AlphaFold DB AlphaFold DB
Domains
Gene Ontology [10]
Biological process:
proteasome-mediated ubiquitin-dependent protein catabolic process proteasomal ubiquitin-independent protein catabolic process proteasomal protein catabolic process
Molecular function:
endopeptidase activator activity
Cellular location:
proteasome core complex proteasome complex proteasome storage granule nucleus proteasome core complex, beta-subunit complex endoplasmic reticulum membrane
proteasome-mediated ubiquitin-dependent protein catabolic process proteasomal ubiquitin-independent protein catabolic process proteasomal protein catabolic process
Molecular function:
endopeptidase activator activity
Cellular location:
proteasome core complex proteasome complex proteasome storage granule nucleus proteasome core complex, beta-subunit complex endoplasmic reticulum membrane
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 22 kDa | - |
Proteasome subunit beta type-5
EC number: 3.4.25.1
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Name: EC number: 3.4.25.1
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [4]
Biological process:
proteasome-mediated ubiquitin-dependent protein catabolic process
Molecular function:
threonine-type endopeptidase activity
Cellular location:
proteasome complex proteasome core complex
proteasome-mediated ubiquitin-dependent protein catabolic process
Molecular function:
threonine-type endopeptidase activity
Cellular location:
proteasome complex proteasome core complex
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 23 kDa | - |
Proteasome subunit beta type-6
EC number: 3.4.25.1
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Name: EC number: 3.4.25.1
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [10]
Biological process:
proteasomal ubiquitin-independent protein catabolic process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process
Molecular function:
threonine-type endopeptidase activity peptidase activity
Cellular location:
proteasome core complex proteasome complex nucleus cytosol proteasome core complex, beta-subunit complex
proteasomal ubiquitin-independent protein catabolic process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process
Molecular function:
threonine-type endopeptidase activity peptidase activity
Cellular location:
proteasome core complex proteasome complex nucleus cytosol proteasome core complex, beta-subunit complex
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 24 kDa | - |
Proteasome subunit beta type-7
EC number: 3.4.25.1
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Molecular function:
threonine-type endopeptidase activity
Cellular location:
proteasome core complex
Name: EC number: 3.4.25.1
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [2]
Molecular function:
threonine-type endopeptidase activity
Cellular location:
proteasome core complex
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 25 kDa | - |
26S proteasome regulatory subunit RPN10
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [2]
Biological process:
ubiquitin-dependent protein catabolic process
Cellular location:
proteasome regulatory particle, base subcomplex
ubiquitin-dependent protein catabolic process
Cellular location:
proteasome regulatory particle, base subcomplex
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 21 kDa | - |
Ubiquitin carboxyl-terminal hydrolase RPN11
EC number: 3.4.19.12
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Name: EC number: 3.4.19.12
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [19]
Biological process:
peroxisome fission proteasome assembly proteasome-mediated ubiquitin-dependent protein catabolic process proteasome storage granule assembly mitochondrial fission protein deubiquitination
Molecular function:
cysteine-type deubiquitinase activity metal ion binding Lys63-specific deubiquitinase activity proteasome binding isopeptidase activity metallopeptidase activity thiol-dependent deubiquitinase
Cellular location:
mitochondrion proteasome complex cytosol proteasome regulatory particle, lid subcomplex nucleus proteasome storage granule
peroxisome fission proteasome assembly proteasome-mediated ubiquitin-dependent protein catabolic process proteasome storage granule assembly mitochondrial fission protein deubiquitination
Molecular function:
cysteine-type deubiquitinase activity metal ion binding Lys63-specific deubiquitinase activity proteasome binding isopeptidase activity metallopeptidase activity thiol-dependent deubiquitinase
Cellular location:
mitochondrion proteasome complex cytosol proteasome regulatory particle, lid subcomplex nucleus proteasome storage granule
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 32 kDa | - |
26S proteasome regulatory subunit RPN12
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [6]
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 31 kDa | - |
26S proteasome regulatory subunit RPN13
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [1]
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 14 kDa | - |
26S proteasome complex subunit SEM1
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [18]
Biological process:
positive regulation of transcription by RNA polymerase II double-strand break repair via homologous recombination proteasome-mediated ubiquitin-dependent protein catabolic process histone deubiquitination maintenance of DNA trinucleotide repeats ubiquitin-dependent protein catabolic process SAGA complex localization to transcription regulatory region filamentous growth proteasome assembly mRNA export from nucleus regulation of cell cycle
Molecular function:
molecular adaptor activity protein folding chaperone
Cellular location:
cytosol transcription export complex 2 proteasome regulatory particle, lid subcomplex proteasome complex proteasome storage granule
positive regulation of transcription by RNA polymerase II double-strand break repair via homologous recombination proteasome-mediated ubiquitin-dependent protein catabolic process histone deubiquitination maintenance of DNA trinucleotide repeats ubiquitin-dependent protein catabolic process SAGA complex localization to transcription regulatory region filamentous growth proteasome assembly mRNA export from nucleus regulation of cell cycle
Molecular function:
molecular adaptor activity protein folding chaperone
Cellular location:
cytosol transcription export complex 2 proteasome regulatory particle, lid subcomplex proteasome complex proteasome storage granule
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 10 kDa | - |
26S proteasome regulatory subunit RPN1
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [11]
Biological process:
ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process regulation of protein catabolic process
Molecular function:
protein-macromolecule adaptor activity enzyme regulator activity
Cellular location:
nucleus proteasome complex cytoplasm proteasome regulatory particle, base subcomplex endoplasmic reticulum proteasome storage granule
ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process regulation of protein catabolic process
Molecular function:
protein-macromolecule adaptor activity enzyme regulator activity
Cellular location:
nucleus proteasome complex cytoplasm proteasome regulatory particle, base subcomplex endoplasmic reticulum proteasome storage granule
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 106 kDa | - |
26S proteasome regulatory subunit RPN2
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [10]
Biological process:
ubiquitin-dependent protein catabolic process regulation of protein catabolic process proteasome assembly proteasome-mediated ubiquitin-dependent protein catabolic process
Molecular function:
enzyme regulator activity ubiquitin protein ligase binding
Cellular location:
proteasome complex proteasome regulatory particle, base subcomplex nucleus proteasome storage granule
ubiquitin-dependent protein catabolic process regulation of protein catabolic process proteasome assembly proteasome-mediated ubiquitin-dependent protein catabolic process
Molecular function:
enzyme regulator activity ubiquitin protein ligase binding
Cellular location:
proteasome complex proteasome regulatory particle, base subcomplex nucleus proteasome storage granule
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 101 kDa | - |
26S proteasome regulatory subunit RPN3
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [6]
Biological process:
proteasome-mediated ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process regulation of protein catabolic process
Molecular function:
enzyme regulator activity
Cellular location:
proteasome regulatory particle, lid subcomplex proteasome complex
proteasome-mediated ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process regulation of protein catabolic process
Molecular function:
enzyme regulator activity
Cellular location:
proteasome regulatory particle, lid subcomplex proteasome complex
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 55 kDa | - |
26S proteasome regulatory subunit RPN5
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [8]
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 51 kDa | - |
26S proteasome regulatory subunit RPN6
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [7]
Biological process:
proteasome assembly proteasome-mediated ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process
Molecular function:
structural molecule activity
Cellular location:
proteasome complex proteasome regulatory particle, lid subcomplex proteasome storage granule
proteasome assembly proteasome-mediated ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process
Molecular function:
structural molecule activity
Cellular location:
proteasome complex proteasome regulatory particle, lid subcomplex proteasome storage granule
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 49 kDa | - |
26S proteasome regulatory subunit RPN7
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [8]
Biological process:
ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process
Molecular function:
structural molecule activity enzyme regulator activity
Cellular location:
proteasome complex proteasome regulatory particle nucleus proteasome regulatory particle, lid subcomplex
ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process
Molecular function:
structural molecule activity enzyme regulator activity
Cellular location:
proteasome complex proteasome regulatory particle nucleus proteasome regulatory particle, lid subcomplex
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 46 kDa | - |
26S proteasome regulatory subunit RPN8
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [7]
Biological process:
proteasome-mediated ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process
Molecular function:
metallopeptidase activity isopeptidase activity
Cellular location:
proteasome regulatory particle, lid subcomplex proteasome complex proteasome storage granule
proteasome-mediated ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process
Molecular function:
metallopeptidase activity isopeptidase activity
Cellular location:
proteasome regulatory particle, lid subcomplex proteasome complex proteasome storage granule
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 34 kDa | - |
26S proteasome regulatory subunit RPN9
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [9]
Biological process:
proteasome assembly ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process
Molecular function:
structural molecule activity
Cellular location:
proteasome complex nucleus proteasome storage granule proteasome regulatory particle, lid subcomplex cytosol
proteasome assembly ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process
Molecular function:
structural molecule activity
Cellular location:
proteasome complex nucleus proteasome storage granule proteasome regulatory particle, lid subcomplex cytosol
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 45 kDa | - |
26S proteasome regulatory subunit 7 homolog
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Molecular function:
ATP binding ATP hydrolysis activity proteasome-activating activity
Cellular location:
cytoplasm
Name: Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [4]
Molecular function:
ATP binding ATP hydrolysis activity proteasome-activating activity
Cellular location:
cytoplasm
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 46 kDa | - |
26S proteasome regulatory subunit 4 homolog
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Molecular function:
ATP binding ATP hydrolysis activity proteasome-activating activity
Cellular location:
cytoplasm
Name: Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [4]
Molecular function:
ATP binding ATP hydrolysis activity proteasome-activating activity
Cellular location:
cytoplasm
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 43 kDa | - |
26S proteasome regulatory subunit 6B homolog
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [12]
Biological process:
positive regulation of RNA polymerase II transcription preinitiation complex assembly ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process proteasome regulatory particle assembly
Molecular function:
identical protein binding proteasome-activating activity ATP hydrolysis activity ATP binding
Cellular location:
proteasome complex proteasome regulatory particle, base subcomplex nucleus cytoplasm
positive regulation of RNA polymerase II transcription preinitiation complex assembly ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process proteasome regulatory particle assembly
Molecular function:
identical protein binding proteasome-activating activity ATP hydrolysis activity ATP binding
Cellular location:
proteasome complex proteasome regulatory particle, base subcomplex nucleus cytoplasm
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 44 kDa | - |
26S proteasome subunit RPT4
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [3]
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 43 kDa | - |
26S proteasome regulatory subunit 6A
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [11]
Biological process:
ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process proteasome regulatory particle assembly positive regulation of RNA polymerase II transcription preinitiation complex assembly
Molecular function:
ATP binding proteasome-activating activity ATP hydrolysis activity
Cellular location:
cytoplasm proteasome complex proteasome regulatory particle, base subcomplex nucleus
ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process proteasome regulatory particle assembly positive regulation of RNA polymerase II transcription preinitiation complex assembly
Molecular function:
ATP binding proteasome-activating activity ATP hydrolysis activity
Cellular location:
cytoplasm proteasome complex proteasome regulatory particle, base subcomplex nucleus
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 46 kDa | - |
26S proteasome regulatory subunit 8 homolog
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [19]
Biological process:
positive regulation of transcription elongation by RNA polymerase II negative regulation of DNA-binding transcription factor activity proteasome-mediated ubiquitin-dependent protein catabolic process nucleotide-excision repair positive regulation of RNA polymerase II transcription preinitiation complex assembly positive regulation of DNA-binding transcription factor activity nonfunctional rRNA decay positive regulation of transcription elongation from RNA polymerase II promoter proteasome regulatory particle assembly chromatin remodeling
Molecular function:
ATP binding proteasome-activating activity ATP hydrolysis activity protein domain specific binding ubiquitin protein ligase binding
Cellular location:
proteasome regulatory particle, base subcomplex nucleus proteasome complex proteasome storage granule
positive regulation of transcription elongation by RNA polymerase II negative regulation of DNA-binding transcription factor activity proteasome-mediated ubiquitin-dependent protein catabolic process nucleotide-excision repair positive regulation of RNA polymerase II transcription preinitiation complex assembly positive regulation of DNA-binding transcription factor activity nonfunctional rRNA decay positive regulation of transcription elongation from RNA polymerase II promoter proteasome regulatory particle assembly chromatin remodeling
Molecular function:
ATP binding proteasome-activating activity ATP hydrolysis activity protein domain specific binding ubiquitin protein ligase binding
Cellular location:
proteasome regulatory particle, base subcomplex nucleus proteasome complex proteasome storage granule
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 45 kDa | - |
ADENOSINE-5'-DIPHOSPHATE
HET code: ADP
Number of copies: 2
ChEMBL ChEBI DrugBank
Name: HET code: ADP
Number of copies: 2
ChEMBL ChEBI DrugBank
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 427 Da | - |
MAGNESIUM ION
HET code: MG
Number of copies: 6
ChEBI DrugBank
Name: HET code: MG
Number of copies: 6
ChEBI DrugBank
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 24 Da | - |
ADENOSINE-5'-TRIPHOSPHATE
HET code: ATP
Number of copies: 4
ChEMBL ChEBI DrugBank
Name: HET code: ATP
Number of copies: 4
ChEMBL ChEBI DrugBank
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 507 Da | - |