EMD-3145 Function and Biology

Mechanism of eIF6 release from the nascent 60S ribosomal subunit

Single particle reconstruction
3.3Å resolution
Overview of EMD-3145
Sample name: Dictyostelium 60S carrying endogenous eIF6 with recombinant human SBDS
Number of unique components: 3

60S ribosomal subunit [Dictyostelium discoideum]

Ribosome-eukaryote type
Name: 60S ribosomal subunit
Experimental weight (MDa): 3

Eukaryotic translation initiation factor 6 [Dictyostelium discoideum]

Protein type
Name: Eukaryotic translation initiation factor 6
Alternative name: eIF6
Experimental weight (MDa): 0.026
Number of copies: 1
UniProt: Q551M2

Shwachman-Bodian-Diamond syndrome protein [Homo sapiens]

Protein type
Name: Shwachman-Bodian-Diamond syndrome protein
Alternative name: SBDS
Experimental weight (MDa): 0.029
Number of copies: 1
UniProt: Q9Y3A5
Expression system
Expression system: Escherichia coli BL21(DE3)
Strain: C41
Vector: pRSETA