EMD-20488 Function and Biology

Human alpha3beta4 nicotinic acetylcholine receptor in complex with AT-1001

Single particle reconstruction
3.87Å resolution
Overview of EMD-20488
Sample name: Human alpha3beta4 nicotinic receptor in complex with Fab fragments and bound to AT-1001
Number of unique components: 18
Details: Fab fragments generated by proteolytic cleavage of IgG antibody

Human alpha3beta4 nicotinic receptor in complex with Fab fragments and bound to AT-1001 [Homo sapiens]

Protein type
Name: Human alpha3beta4 nicotinic receptor in complex with Fab fragments and bound to AT-1001

Human alpha3beta4 nicotinic acetylcholine receptor

Protein type
Name: Human alpha3beta4 nicotinic acetylcholine receptor

Neuronal acetylcholine receptor subunit alpha-3

Protein type
Name: Neuronal acetylcholine receptor subunit alpha-3

Neuronal acetylcholine receptor subunit beta-4

Protein type
Name: Neuronal acetylcholine receptor subunit beta-4

IgG2b/kappa antibody

Protein type
Name: IgG2b/kappa antibody

IgG2b heavy chain

Protein type
Name: IgG2b heavy chain

Kappa Fab light chain

Protein type
Name: Kappa Fab light chain

Fusion protein of Neuronal acetylcholine receptor subunit alpha-3 and Soluble cytochrome b562 [Homo sapiens]

Protein type
Name: Fusion protein of Neuronal acetylcholine receptor subunit alpha-3 and Soluble cytochrome b562
Theoretical weight (MDa): 0.06
Number of copies: 2
Expression system
Expression system: Homo sapiens

Fusion protein of Neuronal acetylcholine receptor subunit beta-4 and Soluble cytochrome b562 [Homo sapiens]

Protein type
Name: Fusion protein of Neuronal acetylcholine receptor subunit beta-4 and Soluble cytochrome b562
Theoretical weight (MDa): 0.061
Number of copies: 3
Expression system
Expression system: Homo sapiens

IgG2b Fab heavy chain [house mouse]

Protein type
Name: IgG2b Fab heavy chain
Theoretical weight (MDa): 0.023
Number of copies: 2

Kappa Fab light chain [house mouse]

Protein type
Name: Kappa Fab light chain
Theoretical weight (MDa): 0.023
Number of copies: 2

(3-endo)-N-(2-bromophenyl)-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine

Ligand type
Name: (3-endo)-N-(2-bromophenyl)-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine
Theoretical weight (MDa): 0
Number of copies: 2

N-ACETYL-D-GLUCOSAMINE

Ligand type
Name: N-ACETYL-D-GLUCOSAMINE
Theoretical weight (MDa): 0
Number of copies: 26

BETA-D-MANNOSE

Ligand type
Name: BETA-D-MANNOSE
Theoretical weight (MDa): 0
Number of copies: 8

ALPHA-D-MANNOSE

Ligand type
Name: ALPHA-D-MANNOSE
Theoretical weight (MDa): 0
Number of copies: 10

CHOLESTEROL HEMISUCCINATE

Ligand type
Name: CHOLESTEROL HEMISUCCINATE
Theoretical weight (MDa): 0
Number of copies: 10

SODIUM ION

Ligand type
Name: SODIUM ION
Theoretical weight (MDa): 0
Number of copies: 1

water

Ligand type
Name: water
Theoretical weight (MDa): 0
Number of copies: 8