EMD-20451
Cryo-EM structure of human TRPA1 C621S mutant in the apo state
EMD-20451
Single-particle2.81 Å
Deposition: 09/07/2019Map released: 08/01/2020
Last modified: 20/03/2024
Name: Transient receptor potential cation channel subfamily A member 1
Name: Transient receptor potential cation channel subfamily A member 1
Natural source [1]
Organism: Homo sapiens
Name: Transient receptor potential cation channel subfamily A member 1
Number of copies: 4
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 4
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [26]
Biological process:
intracellular calcium ion homeostasis monoatomic ion transport response to xenobiotic stimulus detection of chemical stimulus involved in sensory perception of pain sensory perception of pain cell surface receptor signaling pathway thermoception ion transport response to cold detection of mechanical stimulus involved in sensory perception of pain cellular calcium ion homeostasis cellular response to organic substance response to organic cyclic compound response to organic substance calcium ion transmembrane transport protein homotetramerization cellular response to hydrogen peroxide response to pain
Molecular function:
identical protein binding calcium channel activity calcium-release channel activity channel activity temperature-gated cation channel activity
Cellular location:
integral component of plasma membrane plasma membrane stereocilium bundle
intracellular calcium ion homeostasis monoatomic ion transport response to xenobiotic stimulus detection of chemical stimulus involved in sensory perception of pain sensory perception of pain cell surface receptor signaling pathway thermoception ion transport response to cold detection of mechanical stimulus involved in sensory perception of pain cellular calcium ion homeostasis cellular response to organic substance response to organic cyclic compound response to organic substance calcium ion transmembrane transport protein homotetramerization cellular response to hydrogen peroxide response to pain
Molecular function:
identical protein binding calcium channel activity calcium-release channel activity channel activity temperature-gated cation channel activity
Cellular location:
integral component of plasma membrane plasma membrane stereocilium bundle
Natural source
Organism: Homo sapiens
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 131 kDa | - |
Recombinant Expression
| Organism | Strain | Cell | Plasmid |
|---|---|---|---|
| Homo sapiens | - | - | - |
Name: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine
HET code: LBN
Number of copies: 8
ChEBI
HET code: LBN
Number of copies: 8
ChEBI
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 760 Da | - |
Name: [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate
HET code: 6OU
Number of copies: 20
ChEBI
HET code: 6OU
Number of copies: 20
ChEBI
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 717 Da | - |