EMD-20238
Dimeric structure of ACAT1
EMD-20238
Single-particle3.0 Å
Deposition: 21/05/2019
Map released: 20/05/2020
Last modified: 20/03/2024
Name: ACAT1
Name:
Sterol O-acyltransferase 1
EC number: 2.3.1.26
Number of copies: 2
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Name: EC number: 2.3.1.26
Number of copies: 2
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [18]
Biological process:
cholesterol homeostasis low-density lipoprotein particle clearance very-low-density lipoprotein particle assembly cholesterol esterification cholesterol storage positive regulation of amyloid precursor protein biosynthetic process cholesterol efflux cholesterol metabolic process macrophage derived foam cell differentiation
Molecular function:
cholesterol O-acyltransferase activity cholesterol binding sterol O-acyltransferase activity O-acyltransferase activity fatty-acyl-CoA binding
Cellular location:
endoplasmic reticulum membrane endoplasmic reticulum membrane integral component of membrane
cholesterol homeostasis low-density lipoprotein particle clearance very-low-density lipoprotein particle assembly cholesterol esterification cholesterol storage positive regulation of amyloid precursor protein biosynthetic process cholesterol efflux cholesterol metabolic process macrophage derived foam cell differentiation
Molecular function:
cholesterol O-acyltransferase activity cholesterol binding sterol O-acyltransferase activity O-acyltransferase activity fatty-acyl-CoA binding
Cellular location:
endoplasmic reticulum membrane endoplasmic reticulum membrane integral component of membrane
Natural source
Organism: Homo sapiens
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 69 kDa | - |
Recombinant Expression
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Homo sapiens | - | - | - |
S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name)
HET code: 3VV
Number of copies: 2
ChEBI
Name: HET code: 3VV
Number of copies: 2
ChEBI
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 1 kDa | - |