EMD-12806 Function and Biology

Active state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and CNIH2 (LBD-TMD)

Single particle reconstruction
3.6Å resolution
Overview of EMD-12806
Sample name: GluA1/A2 heterotetramer in complex with auxiliary subunits TARP gamma 8 and CNIH2
Number of unique components: 8

GluA1/A2 heterotetramer in complex with auxiliary subunits TARP gamma 8 and CNIH2 [Rattus norvegicus]

Protein type
Name: GluA1/A2 heterotetramer in complex with auxiliary subunits TARP gamma 8 and CNIH2
Theoretical weight (MDa): 0.527
Expression system
Expression system: Homo sapiens

Isoform Flip of Glutamate receptor 1 [Rattus norvegicus]

Protein type
Name: Isoform Flip of Glutamate receptor 1
Theoretical weight (MDa): 0.103
Number of copies: 2
Expression system
Expression system: Homo sapiens

Isoform Flip of Glutamate receptor 2 [Rattus norvegicus]

Protein type
Name: Isoform Flip of Glutamate receptor 2
Theoretical weight (MDa): 0.096
Number of copies: 2
Expression system
Expression system: Homo sapiens

Protein cornichon homolog 2 [Rattus norvegicus]

Protein type
Name: Protein cornichon homolog 2
Theoretical weight (MDa): 0.022
Number of copies: 2
Expression system
Expression system: Homo sapiens

Voltage-dependent calcium channel gamma-8 subunit [Rattus norvegicus]

Protein type
Name: Voltage-dependent calcium channel gamma-8 subunit
Theoretical weight (MDa): 0.044
Number of copies: 2
Expression system
Expression system: Homo sapiens

CYCLOTHIAZIDE

Ligand type
Name: CYCLOTHIAZIDE
Theoretical weight (MDa): 0
Number of copies: 4

1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE

Ligand type
Name: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE
Theoretical weight (MDa): 0.001
Number of copies: 26

GLUTAMIC ACID

Ligand type
Name: GLUTAMIC ACID
Theoretical weight (MDa): 0
Number of copies: 4