EMD-12805
Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and CNIH2 (LBD-TMD)
EMD-12805
Single-particle3.1 Å
Deposition: 26/04/2021
Map released: 09/06/2021
Last modified: 30/06/2021
Name: GluA1/A2 heterotetramer in complex with auxiliary subunits TARP gamma 8 and CNIH2
Summary:
GluA1/A2 heterotetramer in complex with auxiliary subunits TARP gamma 8 and CNIH2
Name: Natural source [1]
Organism: Rattus norvegicus
Recombinant Expression [1]
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Homo sapiens | - | - | - |
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 527 kDa | - |
Complex Portal [1]
ID | Name | Overlap |
---|---|---|
CPX-8766 | GluA1-GluA2 AMPA receptor complex | 0.50 |
Glutamate receptor 1
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [108]
Biological process:
monoatomic ion transmembrane transport synapse assembly chemical synaptic transmission, postsynaptic positive regulation of gene expression ion transmembrane transport cellular response to brain-derived neurotrophic factor stimulus cerebral cortex development neuronal action potential response to arsenic-containing substance cellular response to organic cyclic compound cellular response to ammonium ion cellular response to growth factor stimulus synaptic transmission, glutamatergic regulation of receptor recycling spinal cord development response to toxic substance cellular response to amino acid stimulus regulation of synaptic plasticity response to cocaine modulation of chemical synaptic transmission response to peptide hormone chemical synaptic transmission response to electrical stimulus positive regulation of synaptic transmission response to organic cyclic compound cellular response to dsRNA cellular response to amine stimulus response to lithium ion response to fungicide receptor internalization long-term synaptic depression response to xenobiotic stimulus long-term memory positive regulation of membrane potential cellular response to peptide hormone stimulus response to estradiol regulation of postsynaptic membrane potential
Molecular function:
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential ligand-gated ion channel activity involved in regulation of presynaptic membrane potential G-protein beta-subunit binding protein domain specific binding protein kinase binding protein kinase A binding G-protein alpha-subunit binding scaffold protein binding neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration small GTPase binding glutamate receptor binding myosin V binding protein C-terminus binding adenylate cyclase binding beta-2 adrenergic receptor binding immunoglobulin binding PDZ domain binding transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential amyloid-beta binding AMPA glutamate receptor activity signaling receptor activity ionotropic glutamate receptor activity identical protein binding ligand-gated ion channel activity
Cellular location:
cytoplasm neuronal cell body membrane presynaptic membrane presynaptic active zone membrane dendritic shaft early endosome membrane glutamatergic synapse integral component of presynaptic membrane synaptic membrane postsynaptic density dendritic spine membrane postsynaptic density membrane presynapse neuronal cell body plasma membrane protein-containing complex integral component of postsynaptic density membrane postsynapse cell-cell junction excitatory synapse dendrite membrane perisynaptic space cytosol dendritic spine synaptic vesicle membrane asymmetric synapse early endosome dendrite membrane neuron spine recycling endosome somatodendritic compartment cell surface synaptic vesicle integral component of postsynaptic membrane ionotropic glutamate receptor complex postsynaptic membrane endoplasmic reticulum membrane cell body endoplasmic reticulum neuron projection axonal spine neuromuscular junction synapse AMPA glutamate receptor complex recycling endosome membrane
monoatomic ion transmembrane transport synapse assembly chemical synaptic transmission, postsynaptic positive regulation of gene expression ion transmembrane transport cellular response to brain-derived neurotrophic factor stimulus cerebral cortex development neuronal action potential response to arsenic-containing substance cellular response to organic cyclic compound cellular response to ammonium ion cellular response to growth factor stimulus synaptic transmission, glutamatergic regulation of receptor recycling spinal cord development response to toxic substance cellular response to amino acid stimulus regulation of synaptic plasticity response to cocaine modulation of chemical synaptic transmission response to peptide hormone chemical synaptic transmission response to electrical stimulus positive regulation of synaptic transmission response to organic cyclic compound cellular response to dsRNA cellular response to amine stimulus response to lithium ion response to fungicide receptor internalization long-term synaptic depression response to xenobiotic stimulus long-term memory positive regulation of membrane potential cellular response to peptide hormone stimulus response to estradiol regulation of postsynaptic membrane potential
Molecular function:
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential ligand-gated ion channel activity involved in regulation of presynaptic membrane potential G-protein beta-subunit binding protein domain specific binding protein kinase binding protein kinase A binding G-protein alpha-subunit binding scaffold protein binding neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration small GTPase binding glutamate receptor binding myosin V binding protein C-terminus binding adenylate cyclase binding beta-2 adrenergic receptor binding immunoglobulin binding PDZ domain binding transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential amyloid-beta binding AMPA glutamate receptor activity signaling receptor activity ionotropic glutamate receptor activity identical protein binding ligand-gated ion channel activity
Cellular location:
cytoplasm neuronal cell body membrane presynaptic membrane presynaptic active zone membrane dendritic shaft early endosome membrane glutamatergic synapse integral component of presynaptic membrane synaptic membrane postsynaptic density dendritic spine membrane postsynaptic density membrane presynapse neuronal cell body plasma membrane protein-containing complex integral component of postsynaptic density membrane postsynapse cell-cell junction excitatory synapse dendrite membrane perisynaptic space cytosol dendritic spine synaptic vesicle membrane asymmetric synapse early endosome dendrite membrane neuron spine recycling endosome somatodendritic compartment cell surface synaptic vesicle integral component of postsynaptic membrane ionotropic glutamate receptor complex postsynaptic membrane endoplasmic reticulum membrane cell body endoplasmic reticulum neuron projection axonal spine neuromuscular junction synapse AMPA glutamate receptor complex recycling endosome membrane
Natural source
Organism: Rattus norvegicus
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 102 kDa | - |
Recombinant Expression
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Homo sapiens | - | - | - |
Glutamate receptor 2
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Molecular function:
ionotropic glutamate receptor activity signaling receptor activity ligand-gated ion channel activity
Cellular location:
membrane
Name: Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [4]
Molecular function:
ionotropic glutamate receptor activity signaling receptor activity ligand-gated ion channel activity
Cellular location:
membrane
Natural source
Organism: Rattus norvegicus
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 96 kDa | - |
Recombinant Expression
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Homo sapiens | - | - | - |
Protein cornichon homolog 2
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [20]
Biological process:
regulation of NMDA receptor activity negative regulation of receptor localization to synapse synaptic transmission, glutamatergic regulation of membrane potential localization within membrane regulation of postsynaptic neurotransmitter receptor activity negative regulation of anterograde synaptic vesicle transport vesicle-mediated transport regulation of AMPA receptor activity
Cellular location:
postsynaptic density postsynaptic density membrane dendrite endoplasmic reticulum membrane dendritic shaft postsynaptic membrane dendritic spine AMPA glutamate receptor complex glutamatergic synapse integral component of postsynaptic density membrane synapse
regulation of NMDA receptor activity negative regulation of receptor localization to synapse synaptic transmission, glutamatergic regulation of membrane potential localization within membrane regulation of postsynaptic neurotransmitter receptor activity negative regulation of anterograde synaptic vesicle transport vesicle-mediated transport regulation of AMPA receptor activity
Cellular location:
postsynaptic density postsynaptic density membrane dendrite endoplasmic reticulum membrane dendritic shaft postsynaptic membrane dendritic spine AMPA glutamate receptor complex glutamatergic synapse integral component of postsynaptic density membrane synapse
Natural source
Organism: Rattus norvegicus
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 22 kDa | - |
Recombinant Expression
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Homo sapiens | - | - | - |
Voltage-dependent calcium channel gamma-8 subunit
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [22]
Biological process:
neurotransmitter receptor transport, postsynaptic endosome to lysosome positive regulation of synaptic transmission, glutamatergic positive regulation of AMPA receptor activity neurotransmitter receptor internalization regulation of AMPA receptor activity postsynaptic neurotransmitter receptor diffusion trapping regulation of postsynaptic membrane neurotransmitter receptor levels transmission of nerve impulse
Molecular function:
protein phosphatase 2B binding voltage-gated calcium channel activity ionotropic glutamate receptor binding calcium channel regulator activity channel regulator activity
Cellular location:
L-type voltage-gated calcium channel complex glutamatergic synapse postsynaptic membrane postsynaptic density membrane AMPA glutamate receptor complex dendrite membrane Schaffer collateral - CA1 synapse postsynaptic density integral component of postsynaptic density membrane
neurotransmitter receptor transport, postsynaptic endosome to lysosome positive regulation of synaptic transmission, glutamatergic positive regulation of AMPA receptor activity neurotransmitter receptor internalization regulation of AMPA receptor activity postsynaptic neurotransmitter receptor diffusion trapping regulation of postsynaptic membrane neurotransmitter receptor levels transmission of nerve impulse
Molecular function:
protein phosphatase 2B binding voltage-gated calcium channel activity ionotropic glutamate receptor binding calcium channel regulator activity channel regulator activity
Cellular location:
L-type voltage-gated calcium channel complex glutamatergic synapse postsynaptic membrane postsynaptic density membrane AMPA glutamate receptor complex dendrite membrane Schaffer collateral - CA1 synapse postsynaptic density integral component of postsynaptic density membrane
Natural source
Organism: Rattus norvegicus
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 43 kDa | - |
Recombinant Expression
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Homo sapiens | - | - | - |
6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide
HET code: E2Q
Number of copies: 4
ChEMBL ChEBI
Name: HET code: E2Q
Number of copies: 4
ChEMBL ChEBI
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 336 Da | - |
1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE
HET code: PC1
Number of copies: 46
ChEBI
Name: HET code: PC1
Number of copies: 46
ChEBI
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 790 Da | - |
CHOLESTEROL
HET code: CLR
Number of copies: 2
ChEMBL ChEBI DrugBank
Name: HET code: CLR
Number of copies: 2
ChEMBL ChEBI DrugBank
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 386 Da | - |