EMD-11671 Function and Biology

Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and tariquidar

Single particle reconstruction
3.6Å resolution
Overview of EMD-11671
Sample name: Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and tariquidar
Number of unique components: 8

Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and tariquidar

Protein type
Name: Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and tariquidar
Experimental weight (MDa): 0.24

Multidrug resistance protein 1 [Homo sapiens]

Protein type
Name: Multidrug resistance protein 1
Expression system
Expression system: Homo sapiens

MRK16 Fab-fragment light and heavy chain [Mus musculus]

Protein type
Name: MRK16 Fab-fragment light and heavy chain
Expression system
Expression system: Homo sapiens

Multidrug resistance protein 1 [Homo sapiens]

Protein type
Name: Multidrug resistance protein 1
Theoretical weight (MDa): 0.142
Number of copies: 1
Expression system
Expression system: Homo sapiens

MRK16 Fab-fragment light chain [Mus musculus]

Protein type
Name: MRK16 Fab-fragment light chain
Theoretical weight (MDa): 0.024
Number of copies: 1
Expression system
Expression system: Homo sapiens

MRK16 Fab-fragment heavy chain [Mus musculus]

Protein type
Name: MRK16 Fab-fragment heavy chain
Theoretical weight (MDa): 0.023
Number of copies: 1
Expression system
Expression system: Homo sapiens

tariquidar

Ligand type
Name: tariquidar
Theoretical weight (MDa): 0.001
Number of copies: 2

CHOLESTEROL

Ligand type
Name: CHOLESTEROL
Theoretical weight (MDa): 0
Number of copies: 11