EMD-11667 Function and Biology

Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and vincristine

Single particle reconstruction
3.2Å resolution
Overview of EMD-11667
Sample name: Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and vincristine
Number of unique components: 6

Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and vincristine [Homo sapiens]

Protein type
Name: Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and vincristine
Experimental weight (MDa): 0.24
Expression system
Expression system: Homo sapiens

Multidrug resistance protein 1 [Homo sapiens]

Protein type
Name: Multidrug resistance protein 1
Theoretical weight (MDa): 0.142
Number of copies: 1
Expression system
Expression system: Homo sapiens

MRK16 Fab-fragment light chain [Mus musculus]

Protein type
Name: MRK16 Fab-fragment light chain
Theoretical weight (MDa): 0.024
Number of copies: 1
Expression system
Expression system: Homo sapiens

MRK16 Fab-fragment heavy chain [Mus musculus]

Protein type
Name: MRK16 Fab-fragment heavy chain
Theoretical weight (MDa): 0.023
Number of copies: 1
Expression system
Expression system: Homo sapiens

vincristine

Ligand type
Name: vincristine
Theoretical weight (MDa): 0.001
Number of copies: 1

CHOLESTEROL

Ligand type
Name: CHOLESTEROL
Theoretical weight (MDa): 0
Number of copies: 8