EMD-10577 Function and Biology

PKM2 in complex with Compound 6

Single particle reconstruction
2.5Å resolution
Overview of EMD-10577
Sample name: Pyruvate Kinase M2
Number of unique components: 6

Pyruvate Kinase M2 [Homo sapiens]

Protein type
Name: Pyruvate Kinase M2
Theoretical weight (MDa): 0.24
Expression system
Expression system: Escherichia coli

Pyruvate kinase PKM [Homo sapiens]

Protein type
Name: Pyruvate kinase PKM
Theoretical weight (MDa): 0.06
Number of copies: 4
Expression system
Expression system: Escherichia coli

~{N}-[3-(trifluoromethyl)-1,2-oxazol-5-yl]ethanamide

Ligand type
Name: ~{N}-[3-(trifluoromethyl)-1,2-oxazol-5-yl]ethanamide
Theoretical weight (MDa): 0
Number of copies: 4

BETA-FRUCTOSE-1,6-DIPHOSPHATE

Ligand type
Name: BETA-FRUCTOSE-1,6-DIPHOSPHATE
Theoretical weight (MDa): 0
Number of copies: 4

DIMETHYL SULFOXIDE

Ligand type
Name: DIMETHYL SULFOXIDE
Theoretical weight (MDa): 0
Number of copies: 4

water

Ligand type
Name: water
Theoretical weight (MDa): 0
Number of copies: 220