EMD-10016
Inward-open structure of the ASCT2 (SLC1A5) mutant C467R in presence of TBOA
EMD-10016
Single-particle3.61 Å
Deposition: 03/06/2019
Map released: 07/08/2019
Last modified: 02/12/2020
Name: C467R mutant of ASCT2 (Alanine Serine Cysteine Transporter 2, SLC1A)
Summary:
C467R mutant of ASCT2 (Alanine Serine Cysteine Transporter 2, SLC1A)
Name: Natural source [1]
Organism: Homo sapiens
Recombinant Expression [1]
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Komagataella pastoris | - | - | - |
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 172 kDa | - |
Neutral amino acid transporter B(0)
Number of copies: 3
UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 3
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [28]
Biological process:
erythrocyte differentiation glutamine secretion amino acid transport L-glutamine import across plasma membrane transport across blood-brain barrier neutral amino acid transport protein homotrimerization glutamine transport L-aspartate import across plasma membrane
Molecular function:
antiporter activity ligand-gated channel activity neutral L-amino acid transmembrane transporter activity metal ion binding signaling receptor activity L-glutamine transmembrane transporter activity neutral amino acid transmembrane transporter activity amino acid transmembrane transporter activity symporter activity L-aspartate transmembrane transporter activity L-serine transmembrane transporter activity virus receptor activity
Cellular location:
integral component of plasma membrane plasma membrane membrane basal plasma membrane melanosome integral component of membrane extracellular exosome
erythrocyte differentiation glutamine secretion amino acid transport L-glutamine import across plasma membrane transport across blood-brain barrier neutral amino acid transport protein homotrimerization glutamine transport L-aspartate import across plasma membrane
Molecular function:
antiporter activity ligand-gated channel activity neutral L-amino acid transmembrane transporter activity metal ion binding signaling receptor activity L-glutamine transmembrane transporter activity neutral amino acid transmembrane transporter activity amino acid transmembrane transporter activity symporter activity L-aspartate transmembrane transporter activity L-serine transmembrane transporter activity virus receptor activity
Cellular location:
integral component of plasma membrane plasma membrane membrane basal plasma membrane melanosome integral component of membrane extracellular exosome
Natural source
Organism: Homo sapiens
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 57 kDa | - |
Recombinant Expression
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Komagataella pastoris | - | - | - |