EMD-0955
Cryo-EM structure of 90S small subunit preribosomes in transition states (State C1)
EMD-0955
Single-particle4.8 Å
Deposition: 14/01/2020Map released: 16/09/2020
Last modified: 27/03/2024
Name: 90S pre-ribosome (Dhr1-depleted, state C1)
Summary:
- Complex
- RNA
- Protein
- 40S ribosomal protein S4-A
- 40S ribosomal protein S5
- 40S ribosomal protein S6-A
- 40S ribosomal protein S8-A
- 40S ribosomal protein S9-A
- 40S ribosomal protein S11-A
- 40S ribosomal protein S16-A
- 40S ribosomal protein S23-A
- 40S ribosomal protein S24-A
- 40S ribosomal protein S28-A
- rRNA 2'-O-methyltransferase fibrillarin
- Nucleolar protein 56
- Nucleolar protein 58
- Ribosomal RNA-processing protein 9
- 13 kDa ribonucleoprotein-associated protein
- U3 small nucleolar RNA-associated protein 4
- U3 small nucleolar RNA-associated protein 5
- U3 small nucleolar RNA-associated protein 8
- U3 small nucleolar RNA-associated protein 9
- U3 small nucleolar RNA-associated protein 10
- U3 small nucleolar RNA-associated protein 15
- NET1-associated nuclear protein 1
- Periodic tryptophan protein 2
- U3 small nucleolar RNA-associated protein 12
- U3 small nucleolar RNA-associated protein 13
- U3 small nucleolar RNA-associated protein 18
- U3 small nucleolar RNA-associated protein 21
- U3 small nucleolar RNA-associated protein 6
- Bud site selection protein 21
- U3 small nucleolar RNA-associated protein 7
- U3 small nucleolar RNA-associated protein 11
- U3 small nucleolar RNA-associated protein MPP10
- U3 small nucleolar ribonucleoprotein protein IMP3
- U3 small nucleolar ribonucleoprotein protein IMP4
- Something about silencing protein 10
- Protein SOF1
- rRNA-processing protein FCF2
- rRNA-processing protein FCF1
- Ribosome biogenesis protein ENP2
- U3 small nucleolar ribonucleoprotein protein LCP5
- Ribosomal RNA small subunit methyltransferase NEP1
- Ribosome biogenesis protein BMS1
- RNA 3'-terminal phosphate cyclase-like protein
- RNA cytidine acetyltransferase
- Nucleolar complex protein 14
- Nucleolar complex protein 4
- U3 small nucleolar RNA-associated protein 20
- U3 small nucleolar RNA-associated protein 14
- Essential nuclear protein 1
- Protein BFR2
- Unassigned helices
- Ligand
Name: 90S pre-ribosome (Dhr1-depleted, state C1)
Natural source [1]
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 5 MDa | - |
Name: U3 snoRNA
Number of copies: 1
Number of copies: 1
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 106 kDa | - |
Name: 5' ETS
Number of copies: 1
Number of copies: 1
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 225 kDa | - |
Name: 18S pre-rRNA
Number of copies: 1
Number of copies: 1
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 582 kDa | - |
Name: 40S ribosomal protein S4-A
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [9]
Biological process:
cytoplasmic translation translation
Molecular function:
RNA binding structural constituent of ribosome rRNA binding
Cellular location:
90S preribosome cytosol cytoplasm cytosolic small ribosomal subunit
cytoplasmic translation translation
Molecular function:
RNA binding structural constituent of ribosome rRNA binding
Cellular location:
90S preribosome cytosol cytoplasm cytosolic small ribosomal subunit
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 29 kDa | - |
Name: 40S ribosomal protein S5
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [13]
Biological process:
cytoplasmic translation rRNA export from nucleus translation regulation of translational fidelity ribosomal small subunit assembly
Molecular function:
rRNA binding structural constituent of ribosome mRNA binding
Cellular location:
cytosol 90S preribosome cytoplasm cytosolic small ribosomal subunit ribosome
cytoplasmic translation rRNA export from nucleus translation regulation of translational fidelity ribosomal small subunit assembly
Molecular function:
rRNA binding structural constituent of ribosome mRNA binding
Cellular location:
cytosol 90S preribosome cytoplasm cytosolic small ribosomal subunit ribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 25 kDa | - |
Name: 40S ribosomal protein S6-A
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [10]
Biological process:
translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cytoplasmic translation
Molecular function:
structural constituent of ribosome
Cellular location:
cytosol nucleoplasm small-subunit processome nucleolus cytosolic small ribosomal subunit 90S preribosome
translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cytoplasmic translation
Molecular function:
structural constituent of ribosome
Cellular location:
cytosol nucleoplasm small-subunit processome nucleolus cytosolic small ribosomal subunit 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 27 kDa | - |
Name: 40S ribosomal protein S8-A
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [7]
Biological process:
translation cytoplasmic translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
structural constituent of ribosome
Cellular location:
cytosolic small ribosomal subunit cytosol 90S preribosome
translation cytoplasmic translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
structural constituent of ribosome
Cellular location:
cytosolic small ribosomal subunit cytosol 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 22 kDa | - |
Name: 40S ribosomal protein S9-A
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [15]
Biological process:
translation ribosomal small subunit biogenesis positive regulation of translational fidelity cytoplasmic translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
structural constituent of ribosome rRNA binding
Cellular location:
90S preribosome small-subunit processome small ribosomal subunit cytosolic small ribosomal subunit nucleoplasm cytoplasm nucleolus cytosol
translation ribosomal small subunit biogenesis positive regulation of translational fidelity cytoplasmic translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
structural constituent of ribosome rRNA binding
Cellular location:
90S preribosome small-subunit processome small ribosomal subunit cytosolic small ribosomal subunit nucleoplasm cytoplasm nucleolus cytosol
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 22 kDa | - |
Name: 40S ribosomal protein S11-A
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [9]
Biological process:
translation ribosomal small subunit assembly maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cytoplasmic translation
Molecular function:
rRNA binding structural constituent of ribosome
Cellular location:
cytosolic small ribosomal subunit 90S preribosome cytosol
translation ribosomal small subunit assembly maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cytoplasmic translation
Molecular function:
rRNA binding structural constituent of ribosome
Cellular location:
cytosolic small ribosomal subunit 90S preribosome cytosol
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 17 kDa | - |
Name: 40S ribosomal protein S16-A
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [9]
Biological process:
translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cytoplasmic translation
Molecular function:
RNA binding structural constituent of ribosome
Cellular location:
small ribosomal subunit cytosol cytosolic small ribosomal subunit 90S preribosome
translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cytoplasmic translation
Molecular function:
RNA binding structural constituent of ribosome
Cellular location:
small ribosomal subunit cytosol cytosolic small ribosomal subunit 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 15 kDa | - |
Name: 40S ribosomal protein S23-A
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [8]
Biological process:
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) translation maintenance of translational fidelity regulation of translational fidelity
Molecular function:
structural constituent of ribosome
Cellular location:
ribosome cytosol cytosolic small ribosomal subunit
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) translation maintenance of translational fidelity regulation of translational fidelity
Molecular function:
structural constituent of ribosome
Cellular location:
ribosome cytosol cytosolic small ribosomal subunit
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 16 kDa | - |
Name: 40S ribosomal protein S24-A
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [6]
Biological process:
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cytoplasmic translation
Molecular function:
structural constituent of ribosome
Cellular location:
cytosolic small ribosomal subunit cytosol mitochondrion
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cytoplasmic translation
Molecular function:
structural constituent of ribosome
Cellular location:
cytosolic small ribosomal subunit cytosol mitochondrion
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 15 kDa | - |
Name: 40S ribosomal protein S28-A
Number of copies: 1
UniProtKB UniProtKB PDBe-KB PDBe-KB AlphaFold DB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB PDBe-KB AlphaFold DB AlphaFold DB
Domains
Gene Ontology [7]
Biological process:
ribosomal small subunit assembly translation maturation of SSU-rRNA positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Molecular function:
structural constituent of ribosome
Cellular location:
cytosol cytosolic small ribosomal subunit
ribosomal small subunit assembly translation maturation of SSU-rRNA positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Molecular function:
structural constituent of ribosome
Cellular location:
cytosol cytosolic small ribosomal subunit
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 7 kDa | - |
Name: rRNA 2'-O-methyltransferase fibrillarin
EC number: 2.1.1.-
Number of copies: 2
UniProtKB UniProtKB PDBe-KB AlphaFold DB
EC number: 2.1.1.-
Number of copies: 2
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [20]
Biological process:
maturation of SSU-rRNA rRNA processing histone glutamine methylation regulation of transcription by RNA polymerase I sno(s)RNA processing box C/D RNA 3'-end processing snoRNA guided rRNA 2'-O-methylation rRNA methylation rRNA 2'-O-methylation
Molecular function:
histone H2AQ104 methyltransferase activity histone glutamine N-methyltransferase activity O-methyltransferase activity RNA binding histone-glutamine methyltransferase activity rRNA methyltransferase activity
Cellular location:
box C/D RNP complex 90S preribosome nucleoplasm small-subunit processome nucleolus
maturation of SSU-rRNA rRNA processing histone glutamine methylation regulation of transcription by RNA polymerase I sno(s)RNA processing box C/D RNA 3'-end processing snoRNA guided rRNA 2'-O-methylation rRNA methylation rRNA 2'-O-methylation
Molecular function:
histone H2AQ104 methyltransferase activity histone glutamine N-methyltransferase activity O-methyltransferase activity RNA binding histone-glutamine methyltransferase activity rRNA methyltransferase activity
Cellular location:
box C/D RNP complex 90S preribosome nucleoplasm small-subunit processome nucleolus
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 34 kDa | - |
Name: Nucleolar protein 56
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [13]
Biological process:
maturation of SSU-rRNA snoRNA guided rRNA 2'-O-methylation rRNA modification box C/D RNA 3'-end processing rRNA processing
Molecular function:
mRNA binding snoRNA binding
Cellular location:
small-subunit processome nucleolus nucleoplasm 90S preribosome box C/D RNP complex nucleus
maturation of SSU-rRNA snoRNA guided rRNA 2'-O-methylation rRNA modification box C/D RNA 3'-end processing rRNA processing
Molecular function:
mRNA binding snoRNA binding
Cellular location:
small-subunit processome nucleolus nucleoplasm 90S preribosome box C/D RNP complex nucleus
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 56 kDa | - |
Name: Nucleolar protein 58
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [16]
Biological process:
maturation of SSU-rRNA endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA processing endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) protein localization to nucleolus snoRNA guided rRNA 2'-O-methylation box C/D RNA 3'-end processing
Molecular function:
snRNA binding mRNA binding snoRNA binding
Cellular location:
nucleolus box C/D RNP complex 90S preribosome nucleoplasm small-subunit processome
maturation of SSU-rRNA endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA processing endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) protein localization to nucleolus snoRNA guided rRNA 2'-O-methylation box C/D RNA 3'-end processing
Molecular function:
snRNA binding mRNA binding snoRNA binding
Cellular location:
nucleolus box C/D RNP complex 90S preribosome nucleoplasm small-subunit processome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 57 kDa | - |
Name: Ribosomal RNA-processing protein 9
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [11]
Biological process:
maturation of SSU-rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
snoRNA binding U3 snoRNA binding
Cellular location:
90S preribosome box C/D RNP complex nucleolus nucleoplasm small-subunit processome
maturation of SSU-rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
snoRNA binding U3 snoRNA binding
Cellular location:
90S preribosome box C/D RNP complex nucleolus nucleoplasm small-subunit processome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 65 kDa | - |
Name: 13 kDa ribonucleoprotein-associated protein
Number of copies: 2
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 2
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [22]
Biological process:
spliceosomal complex assembly positive regulation of RNA binding maturation of SSU-rRNA snoRNA guided rRNA 2'-O-methylation box C/D RNA 3'-end processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) mRNA splicing, via spliceosome maturation of LSU-rRNA
Molecular function:
U3 snoRNA binding U4 snRNA binding RNA binding
Cellular location:
cytosolic large ribosomal subunit U4 snRNP nucleus spliceosomal complex U4/U6 snRNP U4/U6 x U5 tri-snRNP complex small-subunit processome precatalytic spliceosome nucleolus box C/D RNP complex nucleoplasm
spliceosomal complex assembly positive regulation of RNA binding maturation of SSU-rRNA snoRNA guided rRNA 2'-O-methylation box C/D RNA 3'-end processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) mRNA splicing, via spliceosome maturation of LSU-rRNA
Molecular function:
U3 snoRNA binding U4 snRNA binding RNA binding
Cellular location:
cytosolic large ribosomal subunit U4 snRNP nucleus spliceosomal complex U4/U6 snRNP U4/U6 x U5 tri-snRNP complex small-subunit processome precatalytic spliceosome nucleolus box C/D RNP complex nucleoplasm
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 13 kDa | - |
Name: U3 small nucleolar RNA-associated protein 4
Number of copies: 1
UniProtKB UniProtKB PDBe-KB PDBe-KB AlphaFold DB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB PDBe-KB AlphaFold DB AlphaFold DB
Domains
Gene Ontology [8]
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 87 kDa | - |
Name: U3 small nucleolar RNA-associated protein 5
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [8]
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 72 kDa | - |
Name: U3 small nucleolar RNA-associated protein 8
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [11]
Biological process:
maturation of SSU-rRNA positive regulation of transcription by RNA polymerase I maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) tRNA export from nucleus
Molecular function:
tRNA binding U3 snoRNA binding
Cellular location:
rDNA heterochromatin 90S preribosome small-subunit processome nucleolus t-UTP complex
maturation of SSU-rRNA positive regulation of transcription by RNA polymerase I maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) tRNA export from nucleus
Molecular function:
tRNA binding U3 snoRNA binding
Cellular location:
rDNA heterochromatin 90S preribosome small-subunit processome nucleolus t-UTP complex
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 80 kDa | - |
Name: U3 small nucleolar RNA-associated protein 9
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [10]
Biological process:
maturation of SSU-rRNA maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) positive regulation of transcription by RNA polymerase I
Molecular function:
U3 snoRNA binding
Cellular location:
nucleus small-subunit processome rDNA heterochromatin 90S preribosome t-UTP complex nucleolus
maturation of SSU-rRNA maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) positive regulation of transcription by RNA polymerase I
Molecular function:
U3 snoRNA binding
Cellular location:
nucleus small-subunit processome rDNA heterochromatin 90S preribosome t-UTP complex nucleolus
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 65 kDa | - |
Name: U3 small nucleolar RNA-associated protein 10
Number of copies: 1
UniProtKB UniProtKB PDBe-KB PDBe-KB AlphaFold DB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB PDBe-KB AlphaFold DB AlphaFold DB
Domains
Gene Ontology [16]
Biological process:
maturation of SSU-rRNA maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) positive regulation of transcription by RNA polymerase I endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
snoRNA binding U3 snoRNA binding
Cellular location:
mitochondrion 90S preribosome nucleolus preribosome, small subunit precursor rDNA heterochromatin nucleoplasm t-UTP complex small-subunit processome
maturation of SSU-rRNA maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) positive regulation of transcription by RNA polymerase I endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
snoRNA binding U3 snoRNA binding
Cellular location:
mitochondrion 90S preribosome nucleolus preribosome, small subunit precursor rDNA heterochromatin nucleoplasm t-UTP complex small-subunit processome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 200 kDa | - |
Name: U3 small nucleolar RNA-associated protein 15
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [11]
Biological process:
maturation of SSU-rRNA positive regulation of transcription by RNA polymerase I rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
U3 snoRNA binding
Cellular location:
rDNA heterochromatin t-UTP complex 90S preribosome nucleoplasm nucleolus small-subunit processome
maturation of SSU-rRNA positive regulation of transcription by RNA polymerase I rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
U3 snoRNA binding
Cellular location:
rDNA heterochromatin t-UTP complex 90S preribosome nucleoplasm nucleolus small-subunit processome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 57 kDa | - |
Name: NET1-associated nuclear protein 1
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [13]
Biological process:
positive regulation of rRNA processing maturation of SSU-rRNA positive regulation of transcription by RNA polymerase I maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
RNA binding mRNA binding U3 snoRNA binding
Cellular location:
nucleolus nucleoplasm rDNA heterochromatin 90S preribosome small-subunit processome t-UTP complex
positive regulation of rRNA processing maturation of SSU-rRNA positive regulation of transcription by RNA polymerase I maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
RNA binding mRNA binding U3 snoRNA binding
Cellular location:
nucleolus nucleoplasm rDNA heterochromatin 90S preribosome small-subunit processome t-UTP complex
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 101 kDa | - |
Name: Periodic tryptophan protein 2
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [15]
Biological process:
maturation of SSU-rRNA establishment of cell polarity maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) septum digestion after cytokinesis endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosomal small subunit assembly
Molecular function:
mRNA binding
Cellular location:
90S preribosome nucleolus cytoplasm nucleoplasm Pwp2p-containing subcomplex of 90S preribosome small-subunit processome
maturation of SSU-rRNA establishment of cell polarity maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) septum digestion after cytokinesis endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosomal small subunit assembly
Molecular function:
mRNA binding
Cellular location:
90S preribosome nucleolus cytoplasm nucleoplasm Pwp2p-containing subcomplex of 90S preribosome small-subunit processome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 104 kDa | - |
Name: U3 small nucleolar RNA-associated protein 12
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [12]
Biological process:
endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
U3 snoRNA binding snoRNA binding
Cellular location:
small-subunit processome 90S preribosome nucleoplasm nucleolus Pwp2p-containing subcomplex of 90S preribosome
endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
U3 snoRNA binding snoRNA binding
Cellular location:
small-subunit processome 90S preribosome nucleoplasm nucleolus Pwp2p-containing subcomplex of 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 106 kDa | - |
Name: U3 small nucleolar RNA-associated protein 13
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [11]
Biological process:
maturation of SSU-rRNA endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
U3 snoRNA binding
Cellular location:
90S preribosome nucleolus nucleoplasm small-subunit processome Pwp2p-containing subcomplex of 90S preribosome
maturation of SSU-rRNA endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
U3 snoRNA binding
Cellular location:
90S preribosome nucleolus nucleoplasm small-subunit processome Pwp2p-containing subcomplex of 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 91 kDa | - |
Name: U3 small nucleolar RNA-associated protein 18
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [10]
Biological process:
maturation of SSU-rRNA endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) RNA fragment catabolic process
Cellular location:
small-subunit processome nucleoplasm Pwp2p-containing subcomplex of 90S preribosome nucleolus 90S preribosome
maturation of SSU-rRNA endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) RNA fragment catabolic process
Cellular location:
small-subunit processome nucleoplasm Pwp2p-containing subcomplex of 90S preribosome nucleolus 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 66 kDa | - |
Name: U3 small nucleolar RNA-associated protein 21
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [9]
Biological process:
maturation of SSU-rRNA ribosomal small subunit biogenesis rRNA processing
Cellular location:
nucleoplasm nucleus small-subunit processome nucleolus Pwp2p-containing subcomplex of 90S preribosome 90S preribosome
maturation of SSU-rRNA ribosomal small subunit biogenesis rRNA processing
Cellular location:
nucleoplasm nucleus small-subunit processome nucleolus Pwp2p-containing subcomplex of 90S preribosome 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 104 kDa | - |
Name: U3 small nucleolar RNA-associated protein 6
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [13]
Biological process:
maturation of SSU-rRNA endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
identical protein binding snoRNA binding U3 snoRNA binding
Cellular location:
small-subunit processome nucleolus nucleoplasm Pwp2p-containing subcomplex of 90S preribosome 90S preribosome
maturation of SSU-rRNA endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
identical protein binding snoRNA binding U3 snoRNA binding
Cellular location:
small-subunit processome nucleolus nucleoplasm Pwp2p-containing subcomplex of 90S preribosome 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 52 kDa | - |
Name: Bud site selection protein 21
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [8]
Biological process:
maturation of SSU-rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
U3 snoRNA binding
Cellular location:
nucleolus small-subunit processome 90S preribosome
maturation of SSU-rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
U3 snoRNA binding
Cellular location:
nucleolus small-subunit processome 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 24 kDa | - |
Name: U3 small nucleolar RNA-associated protein 7
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [10]
Biological process:
maturation of SSU-rRNA endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular location:
90S preribosome nucleoplasm preribosome, small subunit precursor nucleolus small-subunit processome
maturation of SSU-rRNA endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular location:
90S preribosome nucleoplasm preribosome, small subunit precursor nucleolus small-subunit processome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 62 kDa | - |
Name: U3 small nucleolar RNA-associated protein 11
Number of copies: 1
UniProtKB UniProtKB UniProtKB PDBe-KB PDBe-KB AlphaFold DB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB UniProtKB PDBe-KB PDBe-KB AlphaFold DB AlphaFold DB
Domains
Gene Ontology [10]
Biological process:
translation maturation of SSU-rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA processing endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular location:
sno(s)RNA-containing ribonucleoprotein complex small-subunit processome nucleoplasm nucleolus
translation maturation of SSU-rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA processing endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular location:
sno(s)RNA-containing ribonucleoprotein complex small-subunit processome nucleoplasm nucleolus
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 29 kDa | - |
Name: U3 small nucleolar RNA-associated protein MPP10
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [12]
Biological process:
maturation of SSU-rRNA endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
identical protein binding
Cellular location:
90S preribosome sno(s)RNA-containing ribonucleoprotein complex nucleolus Mpp10 complex small-subunit processome nucleus nucleoplasm
maturation of SSU-rRNA endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
identical protein binding
Cellular location:
90S preribosome sno(s)RNA-containing ribonucleoprotein complex nucleolus Mpp10 complex small-subunit processome nucleus nucleoplasm
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 67 kDa | - |
Name: U3 small nucleolar ribonucleoprotein protein IMP3
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [12]
Biological process:
maturation of SSU-rRNA ribosomal small subunit biogenesis rRNA processing
Molecular function:
structural constituent of ribosome snoRNA binding rRNA binding
Cellular location:
small ribosomal subunit nucleolus nucleoplasm small-subunit processome Mpp10 complex 90S preribosome
maturation of SSU-rRNA ribosomal small subunit biogenesis rRNA processing
Molecular function:
structural constituent of ribosome snoRNA binding rRNA binding
Cellular location:
small ribosomal subunit nucleolus nucleoplasm small-subunit processome Mpp10 complex 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 21 kDa | - |
Name: U3 small nucleolar ribonucleoprotein protein IMP4
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [11]
Biological process:
maturation of SSU-rRNA rRNA processing ribosomal small subunit biogenesis
Molecular function:
snoRNA binding single-stranded telomeric DNA binding rRNA primary transcript binding
Cellular location:
nucleolus small-subunit processome nucleoplasm 90S preribosome Mpp10 complex
maturation of SSU-rRNA rRNA processing ribosomal small subunit biogenesis
Molecular function:
snoRNA binding single-stranded telomeric DNA binding rRNA primary transcript binding
Cellular location:
nucleolus small-subunit processome nucleoplasm 90S preribosome Mpp10 complex
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 33 kDa | - |
Name: Something about silencing protein 10
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [11]
Biological process:
maturation of SSU-rRNA cell cycle endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
identical protein binding
Cellular location:
small-subunit processome nucleoplasm nucleolus nucleus
maturation of SSU-rRNA cell cycle endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
identical protein binding
Cellular location:
small-subunit processome nucleoplasm nucleolus nucleus
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 70 kDa | - |
Name: Protein SOF1
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [8]
Biological process:
maturation of SSU-rRNA maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
mRNA binding
Cellular location:
Cul4-RING E3 ubiquitin ligase complex 90S preribosome nucleolus nucleoplasm small-subunit processome
maturation of SSU-rRNA maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
mRNA binding
Cellular location:
Cul4-RING E3 ubiquitin ligase complex 90S preribosome nucleolus nucleoplasm small-subunit processome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 56 kDa | - |
Name: rRNA-processing protein FCF2
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [6]
Biological process:
endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) RNA processing
Cellular location:
nucleolus nucleus
endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) RNA processing
Cellular location:
nucleolus nucleus
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 25 kDa | - |
Name: rRNA-processing protein FCF1
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [9]
Biological process:
maturation of SSU-rRNA endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
RNA endonuclease activity endoribonuclease activity
Cellular location:
nucleoplasm small-subunit processome nucleolus
maturation of SSU-rRNA endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
RNA endonuclease activity endoribonuclease activity
Cellular location:
nucleoplasm small-subunit processome nucleolus
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 21 kDa | - |
Name: Ribosome biogenesis protein ENP2
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [5]
Biological process:
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosomal small subunit biogenesis
Cellular location:
small-subunit processome nucleolus 90S preribosome
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosomal small subunit biogenesis
Cellular location:
small-subunit processome nucleolus 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 81 kDa | - |
Name: U3 small nucleolar ribonucleoprotein protein LCP5
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [8]
Biological process:
maturation of SSU-rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular location:
small nuclear ribonucleoprotein complex nucleolus small-subunit processome sno(s)RNA-containing ribonucleoprotein complex
maturation of SSU-rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular location:
small nuclear ribonucleoprotein complex nucleolus small-subunit processome sno(s)RNA-containing ribonucleoprotein complex
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 40 kDa | - |
Name: Ribosomal RNA small subunit methyltransferase NEP1
EC number: 2.1.1.260
Number of copies: 2
UniProtKB UniProtKB PDBe-KB AlphaFold DB
EC number: 2.1.1.260
Number of copies: 2
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [19]
Biological process:
maturation of SSU-rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosomal small subunit biogenesis rRNA methylation endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA processing endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA base methylation
Molecular function:
identical protein binding rRNA (pseudouridine) methyltransferase activity rRNA binding
Cellular location:
cytoplasm nuclear periphery nucleoplasm 90S preribosome small-subunit processome nuclear microtubule nucleolus nucleus
maturation of SSU-rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosomal small subunit biogenesis rRNA methylation endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA processing endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA base methylation
Molecular function:
identical protein binding rRNA (pseudouridine) methyltransferase activity rRNA binding
Cellular location:
cytoplasm nuclear periphery nucleoplasm 90S preribosome small-subunit processome nuclear microtubule nucleolus nucleus
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 27 kDa | - |
Name: Ribosome biogenesis protein BMS1
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [20]
Biological process:
maturation of SSU-rRNA ribosomal small subunit biogenesis endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) regulation of rRNA processing
Molecular function:
mRNA binding GTP binding ATP hydrolysis activity ATP binding GTPase activity U3 snoRNA binding
Cellular location:
mitochondrion small-subunit processome nucleoplasm nucleus nucleolus cytoplasm 90S preribosome
maturation of SSU-rRNA ribosomal small subunit biogenesis endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) regulation of rRNA processing
Molecular function:
mRNA binding GTP binding ATP hydrolysis activity ATP binding GTPase activity U3 snoRNA binding
Cellular location:
mitochondrion small-subunit processome nucleoplasm nucleus nucleolus cytoplasm 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 135 kDa | - |
Name: RNA 3'-terminal phosphate cyclase-like protein
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [15]
Biological process:
maturation of SSU-rRNA ribosomal small subunit biogenesis rRNA processing endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) regulation of rRNA processing
Molecular function:
RNA endonuclease activity enzyme activator activity endoribonuclease activity
Cellular location:
90S preribosome nucleolus small-subunit processome nucleoplasm
maturation of SSU-rRNA ribosomal small subunit biogenesis rRNA processing endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) regulation of rRNA processing
Molecular function:
RNA endonuclease activity enzyme activator activity endoribonuclease activity
Cellular location:
90S preribosome nucleolus small-subunit processome nucleoplasm
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 40 kDa | - |
Name: RNA cytidine acetyltransferase
EC number: 2.3.1.-
Number of copies: 2
UniProtKB UniProtKB PDBe-KB AlphaFold DB
EC number: 2.3.1.-
Number of copies: 2
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [13]
Biological process:
maturation of SSU-rRNA ribosomal small subunit biogenesis rRNA acetylation involved in maturation of SSU-rRNA mRNA modification tRNA acetylation
Molecular function:
ATP binding tRNA binding snoRNA binding rRNA cytidine N-acetyltransferase activity
Cellular location:
preribosome, small subunit precursor 90S preribosome small-subunit processome nucleolus
maturation of SSU-rRNA ribosomal small subunit biogenesis rRNA acetylation involved in maturation of SSU-rRNA mRNA modification tRNA acetylation
Molecular function:
ATP binding tRNA binding snoRNA binding rRNA cytidine N-acetyltransferase activity
Cellular location:
preribosome, small subunit precursor 90S preribosome small-subunit processome nucleolus
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 119 kDa | - |
Name: Nucleolar complex protein 14
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [17]
Biological process:
ribosomal small subunit assembly rRNA processing maturation of SSU-rRNA maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosomal small subunit biogenesis endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
U3 snoRNA binding
Cellular location:
nucleus preribosome, small subunit precursor mitochondrion Noc4p-Nop14p complex small-subunit processome nucleolus 90S preribosome nucleoplasm
ribosomal small subunit assembly rRNA processing maturation of SSU-rRNA maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosomal small subunit biogenesis endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
U3 snoRNA binding
Cellular location:
nucleus preribosome, small subunit precursor mitochondrion Noc4p-Nop14p complex small-subunit processome nucleolus 90S preribosome nucleoplasm
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 94 kDa | - |
Name: Nucleolar complex protein 4
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [15]
Biological process:
maturation of SSU-rRNA ribosomal small subunit assembly rRNA processing endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosomal small subunit biogenesis endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular location:
nucleus preribosome, small subunit precursor 90S preribosome cytosol nucleolus nucleoplasm Noc4p-Nop14p complex small-subunit processome
maturation of SSU-rRNA ribosomal small subunit assembly rRNA processing endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosomal small subunit biogenesis endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular location:
nucleus preribosome, small subunit precursor 90S preribosome cytosol nucleolus nucleoplasm Noc4p-Nop14p complex small-subunit processome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 63 kDa | - |
Name: U3 small nucleolar RNA-associated protein 20
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [11]
Biological process:
maturation of SSU-rRNA endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
mRNA binding
Cellular location:
nucleoplasm nucleolus 90S preribosome preribosome, small subunit precursor cytoplasm small-subunit processome
maturation of SSU-rRNA endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
mRNA binding
Cellular location:
nucleoplasm nucleolus 90S preribosome preribosome, small subunit precursor cytoplasm small-subunit processome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 287 kDa | - |
Name: U3 small nucleolar RNA-associated protein 14
Number of copies: 1
UniProtKB UniProtKB UniProtKB PDBe-KB PDBe-KB AlphaFold DB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB UniProtKB PDBe-KB PDBe-KB AlphaFold DB AlphaFold DB
Domains
Gene Ontology [8]
Biological process:
maturation of SSU-rRNA endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
ATP binding
Cellular location:
nucleolus nucleoplasm small-subunit processome
maturation of SSU-rRNA endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
ATP binding
Cellular location:
nucleolus nucleoplasm small-subunit processome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 103 kDa | - |
Name: Essential nuclear protein 1
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [11]
Biological process:
maturation of SSU-rRNA poly(A)+ mRNA export from nucleus rRNA processing endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
snoRNA binding
Cellular location:
preribosome, small subunit precursor nucleolus small-subunit processome nucleus cytoplasm 90S preribosome
maturation of SSU-rRNA poly(A)+ mRNA export from nucleus rRNA processing endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
snoRNA binding
Cellular location:
preribosome, small subunit precursor nucleolus small-subunit processome nucleus cytoplasm 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 55 kDa | - |
Name: Protein BFR2
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [7]
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 61 kDa | - |
Name: Unassigned helices
Number of copies: 1
Number of copies: 1
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 29 kDa | - |
Name: ZINC ION
HET code: ZN
Number of copies: 1
ChEMBL ChEBI DrugBank
HET code: ZN
Number of copies: 1
ChEMBL ChEBI DrugBank
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 65 Da | - |
Name: GUANOSINE-5'-TRIPHOSPHATE
HET code: GTP
Number of copies: 1
ChEMBL ChEBI DrugBank
HET code: GTP
Number of copies: 1
ChEMBL ChEBI DrugBank
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 523 Da | - |
Name: MAGNESIUM ION
HET code: MG
Number of copies: 1
ChEBI DrugBank
HET code: MG
Number of copies: 1
ChEBI DrugBank
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 24 Da | - |