7rhi

Electron Microscopy
3.31Å resolution

Cryo-EM structure of human rod CNGA1/B1 channel in cGMP-bound openII state

Released:
Source organism: Homo sapiens
Related structures: EMD-24462

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-151592 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cyclic nucleotide-gated channel alpha-1 Chains: A, C, D
Molecule details ›
Chains: A, C, D
Length: 560 amino acids
Theoretical weight: 64.65 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P29973 (Residues: 140-686; Coverage: 80%)
Gene names: CNCG, CNCG1, CNGA1
Sequence domains:
Cyclic nucleotide-gated channel beta-1 Chain: B
Molecule details ›
Chain: B
Length: 810 amino acids
Theoretical weight: 91.04 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q14028 (Residues: 454-1251; Coverage: 64%)
Gene names: CNCG2, CNCG3L, CNCG4, CNGB1, RCNC2
Sequence domains: Cyclic nucleotide-binding domain

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.31Å
Relevant EMDB volumes: EMD-24462
Expression system: Homo sapiens