› 7npw

Electron Microscopy
3.99Å resolution

Cryo-EM structure of Human excitatory amino acid transporters-1 (EAAT1) in potassium buffer

Released:
DOI: 10.2210/pdb7npw/pdb
PDB entry 7npw coloured by chain, front view.
PDB entry 7npw coloured by chain, side view.
PDB entry 7npw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The ion-coupling mechanism of human excitatory amino acid transporters.
Canul-Tec JC, Kumar A, Dhenin J, Assal R, Legrand P, Rey M, Chamot-Rooke J, Reyes N
EMBO J 41 e108341 (2022)
PMID: 34747040
Related structures: EMD-12524

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154929 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Excitatory amino acid transporter 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 469 amino acids
Theoretical weight: 51.08 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P43003 (Residues: 29-497; Coverage: 87%)
Gene names: EAAT1, GLAST, GLAST1, SLC1A3
Sequence domains: Sodium:dicarboxylate symporter family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.99Å
Relevant EMDB volumes: EMD-12524
Expression system: Homo sapiens

Quick links

Citations

1 review citation

Stress-Induced Depression and Alzheimer's Disease: Focus on Astrocytes.
Dolotov et al. (2022)
7 other articles

1 mention without citation

The ion-coupling mechanism of human excitatory amino acid transporters.
Canul-Tec et al. (2022)