› 7m98

X-ray diffraction
1.6Å resolution

ATAD2 bromodomain complexed with histone H4K5ac (res 1-10) ligand

Released:
DOI: 10.2210/pdb7m98/pdb
PDB entry 7m98 coloured by chain, front view.
PDB entry 7m98 coloured by chain, side view.
PDB entry 7m98 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Coordination of Di-Acetylated Histone Ligands by the ATAD2 Bromodomain.
Evans CM, Phillips M, Malone KL, Tonelli M, Cornilescu G, Cornilescu C, Holton SJ, Gorjánácz M, Wang L, Carlson S, Gay JC, Nix JC, Demeler B, Markley JL, Glass KC
Int J Mol Sci 22 (2021)
PMID: 34502039

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158681 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
ATPase family AAA domain-containing protein 2 Chain: A
Molecule details ›
Chain: A
Length: 152 amino acids
Theoretical weight: 17.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q6PL18 (Residues: 966-1112; Coverage: 11%)
Gene names: ATAD2, L16, PRO2000
Sequence domains: Bromodomain
Histone H4 Chain: B
Molecule details ›
Chain: B
Length: 15 amino acids
Theoretical weight: 1.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P62805 (Residues: 2-16; Coverage: 15%)
Gene names: H4-16, H4/A, H4/B, H4/C, H4/D, H4/E, H4/G, H4/H, H4/I, H4/J, H4/K, H4/M, H4/N, H4/O, H4C1, H4C11, H4C12, H4C13, H4C14, H4C15, H4C16, H4C2, H4C3, H4C4, H4C5, H4C6, H4C8, H4C9, H4F2, H4FA, H4FB, H4FC, H4FD, H4FE, H4FG, H4FH, H4FI, H4FJ, H4FK, H4FM, H4FN, H4FO, HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4, HIST2H4A, HIST2H4B, HIST4H4

Ligands and Environments

No bound ligands
1 modified residue:
Ligand ALY 1 x ALY

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P4322
Unit cell:
a: 53.56Å b: 53.56Å c: 160.35Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.194 0.219
Expression system: Escherichia coli BL21

Quick links

Citations

4 review citations

Alterations of Chromatin Regulators in the Pathogenesis of Urinary Bladder Urothelial Carcinoma.
Hoffmann et al. (2021)
3 more

1 mention without citation

Coordination of Di-Acetylated Histone Ligands by the ATAD2 Bromodomain.
Evans et al. (2021)