7m10

X-ray diffraction
1.15Å resolution

PHF2 PHD Domain Complexed with Peptide From N-terminus of VRK1

Released:
Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-130855 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Lysine-specific demethylase PHF2 Chain: A
Molecule details ›
Chain: A
Length: 74 amino acids
Theoretical weight: 8.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O75151 (Residues: 1-70; Coverage: 6%)
Gene names: CENP-35, KIAA0662, PHF2
Sequence domains: PHD-finger
Serine/threonine-protein kinase VRK1 Chain: B
Molecule details ›
Chain: B
Length: 12 amino acids
Theoretical weight: 1.31 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q99986 (Residues: 2-13; Coverage: 3%)
Gene name: VRK1

Ligands and Environments

2 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: I222
Unit cell:
a: 34.24Å b: 63.717Å c: 103.152Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.157 0.156 0.165
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided