› 7kj7

X-ray diffraction
2.8Å resolution

Plasmodium falciparum protein Pf12p

Released:
DOI: 10.2210/pdb7kj7/pdb
PDB entry 7kj7 coloured by chain, front view.
PDB entry 7kj7 coloured by chain, side view.
PDB entry 7kj7 coloured by chain, top view.
Source organism: Plasmodium falciparum 3D7
Primary publication:
Nanobody generation and structural characterization of Plasmodium falciparum 6-cysteine protein Pf12p.
Dietrich MH, Chan LJ, Adair A, Keremane S, Pymm P, Lo AW, Cao YC, Tham WH
Biochem J 478 579-595 (2021)
PMID: 33480416

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-111611 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Surface protein P12p Chains: A, B
Molecule details ›
Chains: A, B
Length: 321 amino acids
Theoretical weight: 37.25 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: C6KSX1 (Residues: 24-341; Coverage: 91%)
Gene names: PF12P, PFF0620c, PFS12P
Sequence domains: Sexual stage antigen s48/45 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P212121
Unit cell:
a: 51.999Å b: 74.175Å c: 183.929Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.253 0.25 0.295
Expression system: Spodoptera frugiperda

Quick links

Citations

2 review citations

Chemical Biology Tools To Investigate Malaria Parasites.
Broichhagen et al. (2021)
1 more

2 mentions without citation

Plasmodium 6-Cysteine Proteins: Functional Diversity, Transmission-Blocking Antibodies and Structural Scaffolds.
Lyons et al. (2022)
1 more