› 7kh8

X-ray diffraction
1.3Å resolution

Function and Biology Details

Reactions catalysed: 
A phosphate monoester + H(2)O = an alcohol + phosphate
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150269 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Low molecular weight phosphotyrosine protein phosphatase Chains: A, B
Molecule details ›
Chains: A, B
Length: 157 amino acids
Theoretical weight: 17.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P24666 (Residues: 5-158; Coverage: 98%)
Gene name: ACP1
Sequence domains: Low molecular weight phosphotyrosine protein phosphatase

Ligands and Environments

2 bound ligands:
Ligand WE7 2 x WE7
Ligand NO3 2 x NO3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P212121
Unit cell:
a: 54.971Å b: 58.96Å c: 95.088Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.127 0.125 0.161
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Targeting protein phosphatases in cancer immunotherapy and autoimmune disorders.
Stanford et al. (2023)
1 other article

2 mentions without citation

Discovery of Orally Bioavailable Purine-Based Inhibitors of the Low-Molecular-Weight Protein Tyrosine Phosphatase.
Stanford et al. (2021)
1 more