› 7k9v

X-ray diffraction
1.91Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-125439 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histidine kinase/HSP90-like ATPase domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 219 amino acids
Theoretical weight: 24.47 KDa
Source organism: Cryptococcus neoformans
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: J9VVA4 (Residues: 1-215; Coverage: 31%)
Gene name: CNAG_06150
Sequence domains: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

Ligands and Environments

4 bound ligands:
Ligand W8V 2 x W8V
Ligand BEN 2 x BEN
Ligand GOL 1 x GOL
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS-II BEAMLINE 17-ID-2
Spacegroup: C2
Unit cell:
a: 145.562Å b: 44.289Å c: 78Å
α: 90° β: 104.355° γ: 90°
R-values:
R R work R free
0.165 0.164 0.194
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'

Quick links

Citations

1 review citation

Treatment of Cryptococcal Meningitis: How Have We Got Here and Where are We Going?
Ngan et al. (2022)
4 other articles

3 mentions without citation

Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors: Optimization of Whole-Cell Anticryptococcal Activity and Insights into the Structural Origins of Cryptococcal Selectivity.
Marcyk et al. (2021)
2 more