7k8m

X-ray diffraction
3.2Å resolution

Structure of the SARS-CoV-2 receptor binding domain in complex with the human neutralizing antibody Fab fragment, C102

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-209787 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
C102 Fab Heavy Chain Chain: A
Molecule details ›
Chain: A
Length: 229 amino acids
Theoretical weight: 24.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
C102 Fab Light Chain Chain: B
Molecule details ›
Chain: B
Length: 215 amino acids
Theoretical weight: 23.42 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Spike protein S1 Chain: E
Molecule details ›
Chain: E
Length: 187 amino acids
Theoretical weight: 21.15 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 331-517; Coverage: 15%)
Gene names: 2, S
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-1
Spacegroup: P212121
Unit cell:
a: 54.599Å b: 89.25Å c: 175.089Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.175 0.234
Expression system: Homo sapiens