› 7k4c

Electron Microscopy
3.78Å resolution

Cryo-EM structure of human TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor Br-cis-22a

Released:
DOI: 10.2210/pdb7k4c/pdb
PDB entry 7k4c coloured by chain, front view.
PDB entry 7k4c coloured by chain, side view.
PDB entry 7k4c coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Inactivation-mimicking block of the epithelial calcium channel TRPV6.
Bhardwaj R, Lindinger S, Neuberger A, Nadezhdin KD, Singh AK, Cunha MR, Derler I, Gyimesi G, Reymond JL, Hediger MA, Romanin C, Sobolevsky AI
Sci Adv 6 (2020)
PMID: 33246965
Related structures: EMD-22664

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190512 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 6 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 670 amino acids
Theoretical weight: 77.02 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9H1D0 (Residues: 41-707; Coverage: 87%)
Gene names: ECAC2, TRPV6
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand 81F 5 x 81F
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.78Å
Relevant EMDB volumes: EMD-22664
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Calcium Signalling in Breast Cancer Associated Bone Pain.
Bortolin et al. (2022)
1 more

1 mention without citation

Ligand-Binding Sites in Vanilloid-Subtype TRP Channels.
Yelshanskaya et al. (2022)