Function and Biology Details
Reaction catalysed:
Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Proliferating cell nuclear antigen, PCNA
- Adenine DNA glycosylase, C-terminal
- Proliferating cell nuclear antigen, PCNA, conserved site
- DNA clamp superfamily
- NUDIX hydrolase domain
- Adenine/Thymine-DNA glycosylase
- Proliferating cell nuclear antigen, PCNA, C-terminal
- Proliferating cell nuclear antigen, PCNA, N-terminal
Structure analysis Details
Assembly composition:
hetero hexamer (preferred)
Assembly name:
PCNA homotrimer and Adenine DNA glycosylase (preferred)
PDBe Complex ID:
PDB-CPX-146063 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
PHOTON FACTORY BEAMLINE BL-17A
Spacegroup:
P63
Expression system: Escherichia coli