› 7d35

X-ray diffraction
2.4Å resolution

Human LC8 bound to ebola virus VP35(67-76)

Released:
DOI: 10.2210/pdb7d35/pdb
PDB entry 7d35 coloured by chain, front view.
PDB entry 7d35 coloured by chain, side view.
PDB entry 7d35 coloured by chain, top view.
Source organisms:
Primary publication:
Crystal structure of human LC8 bound to a peptide from Ebola virus VP35.
Lim D, Shin HC, Choi JS, Kim SJ, Ku B
J Microbiol 59 410-416 (2021)
PMID: 33630249

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159025 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Dynein light chain 1, cytoplasmic Chain: A
Molecule details ›
Chain: A
Length: 91 amino acids
Theoretical weight: 10.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P63167 (Residues: 1-89; Coverage: 100%)
Gene names: DLC1, DNCL1, DNCLC1, DYNLL1, HDLC1
Sequence domains: Dynein light chain type 1
Polymerase cofactor VP35 Chain: B
Molecule details ›
Chain: B
Length: 10 amino acids
Theoretical weight: 1.18 KDa
Source organism: Ebola virus
Expression system: Not provided
UniProt:
  • Canonical: Q05127 (Residues: 67-76; Coverage: 3%)
Gene name: VP35

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 7A (6B, 6C1)
Spacegroup: P6122
Unit cell:
a: 43.426Å b: 43.426Å c: 205.19Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.234 0.228 0.292
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

3 citation in other articles

Borna Disease Virus 1 Phosphoprotein Forms a Tetramer and Interacts with Host Factors Involved in DNA Double-Strand Break Repair and mRNA Processing.
Tarbouriech et al. (2022)
2 more