› 7ceb

X-ray diffraction
2.89Å resolution

Crystal structure of alpha6beta1 integrin headpiece

Released:
DOI: 10.2210/pdb7ceb/pdb
PDB entry 7ceb coloured by chain, front view.
PDB entry 7ceb coloured by chain, side view.
PDB entry 7ceb coloured by chain, top view.
Source organisms:
Primary publication:
Structural mechanism of laminin recognition by integrin.
Arimori T, Miyazaki N, Mihara E, Takizawa M, Taniguchi Y, Cabañas C, Sekiguchi K, Takagi J
Nat Commun 12 4012 (2021)
PMID: 34188035

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138716 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Integrin alpha-6 heavy chain Chain: A
Molecule details ›
Chain: A
Length: 627 amino acids
Theoretical weight: 69.78 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P23229 (Residues: 24-680; Coverage: 56%)
Gene name: ITGA6
Sequence domains:
Integrin beta-1 Chain: B
Molecule details ›
Chain: B
Length: 454 amino acids
Theoretical weight: 50.51 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P05556 (Residues: 21-465; Coverage: 57%)
Gene names: FNRB, ITGB1, MDF2, MSK12
Sequence domains:
Serine/threonine-protein kinase 4 18kDa subunit Chain: C
Molecule details ›
Chain: C
Length: 172 amino acids
Theoretical weight: 19.46 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13043 (Residues: 431-480; Coverage: 10%)
Gene names: KRS2, MST1, STK4
Sequence domains: C terminal SARAH domain of Mst1
Serine/threonine-protein kinase 4 18kDa subunit Chain: D
Molecule details ›
Chain: D
Length: 164 amino acids
Theoretical weight: 18.27 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13043 (Residues: 412-480; Coverage: 14%)
Gene names: KRS2, MST1, STK4
Sequence domains: C terminal SARAH domain of Mst1

Ligands and Environments

3 bound ligands:
Ligand CA 4 x CA
Ligand NAG 6 x NAG
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE TPS 05A
Spacegroup: P21212
Unit cell:
a: 116.52Å b: 251.31Å c: 63.25Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.207 0.249
Expression systems:
  • Homo sapiens
  • Escherichia coli

Quick links

Citations

4 review citations

Cell-specific expression and function of laminin at the neurovascular unit.
Nirwane et al. (2022)
3 more

1 mention without citation

Integrating Network Pharmacology Approaches to Decipher the Multi-Target Pharmacological Mechanism of Microbial Biosurfactants as Novel Green Antimicrobials against Listeriosis.
Adnan et al. (2022)