› 7cd1

X-ray diffraction
1.89Å resolution

Crystal structure of inhibitory Smad, Smad7

Released:
DOI: 10.2210/pdb7cd1/pdb
PDB entry 7cd1 coloured by chain, front view.
PDB entry 7cd1 coloured by chain, side view.
PDB entry 7cd1 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis for inhibitory effects of Smad7 on TGF-β family signaling.
Murayama K, Kato-Murayama M, Itoh Y, Miyazono K, Miyazawa K, Shirouzu M
J Struct Biol 212 107661 (2020)
PMID: 33166654

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128663 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mothers against decapentaplegic homolog 7 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 187 amino acids
Theoretical weight: 21.47 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: O35253 (Residues: 247-426; Coverage: 42%)
Gene names: Madh7, Madh8, Smad7
Sequence domains: MH2 domain

Ligands and Environments

2 bound ligands:
Ligand SO4 8 x SO4
Ligand CL 7 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL32XU
Spacegroup: C2221
Unit cell:
a: 93.205Å b: 117.426Å c: 163.239Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.175 0.174 0.199
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Molecular Mechanistic Pathways Targeted by Natural Antioxidants in the Prevention and Treatment of Chronic Kidney Disease.
Mohany et al. (2021)
1 more