› 7c04

X-ray diffraction
1.7Å resolution

Crystal structure of human Trap1 with DN203492

Released:
DOI: 10.2210/pdb7c04/pdb
PDB entry 7c04 coloured by chain, front view.
PDB entry 7c04 coloured by chain, side view.
PDB entry 7c04 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Development of pyrazolo[3,4-d]pyrimidine-6-amine-based TRAP1 inhibitors that demonstrate in vivo anticancer activity in mouse xenograft models.
Kim D, Kim SY, Kim D, Yoon NG, Yun J, Hong KB, Lee C, Lee JH, Kang BH, Kang S
Bioorg Chem 101 103901 (2020)
PMID: 32590225

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171444 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heat shock protein 75 kDa, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 235 amino acids
Theoretical weight: 25.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q12931 (Residues: 60-294; Coverage: 33%)
Gene names: HSP75, HSPC5, TRAP1

Ligands and Environments

1 bound ligand:
Ligand FEU 1 x FEU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 7A (6B, 6C1)
Spacegroup: R3
Unit cell:
a: 110.405Å b: 110.405Å c: 59.445Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.191 0.189 0.234
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

TRAP1 in Oxidative Stress and Neurodegeneration.
Ramos Rego et al. (2021)
1 more