7c01

X-ray diffraction
2.88Å resolution

Molecular basis for a potent human neutralizing antibody targeting SARS-CoV-2 RBD

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-209705 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Spike protein S1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 229 amino acids
Theoretical weight: 25.95 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 319-541; Coverage: 18%)
Gene names: 2, S
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding
CB6 heavy chain Chains: C, H
Molecule details ›
Chains: C, H
Length: 233 amino acids
Theoretical weight: 24.95 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
CB6 light chain Chains: D, L
Molecule details ›
Chains: D, L
Length: 217 amino acids
Theoretical weight: 23.72 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P212121
Unit cell:
a: 87.4Å b: 106.73Å c: 170.59Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.218 0.265
Expression system: Homo sapiens