› 7b35

X-ray diffraction
2.4Å resolution

MST3 in complex with compound MRIA13

Released:
DOI: 10.2210/pdb7b35/pdb
PDB entry 7b35 coloured by chain, front view.
PDB entry 7b35 coloured by chain, side view.
PDB entry 7b35 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure-Based Design of Selective Salt-Inducible Kinase Inhibitors.
Tesch R, Rak M, Raab M, Berger LM, Kronenberger T, Joerger AC, Berger BT, Abdi I, Hanke T, Poso A, Strebhardt K, Sanhaji M, Knapp S
J Med Chem 64 8142-8160 (2021)
PMID: 34086472

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195356 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase 24 36 kDa subunit Chains: A, B
Molecule details ›
Chains: A, B
Length: 306 amino acids
Theoretical weight: 34.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y6E0 (Residues: 4-301; Coverage: 67%)
Gene names: MST3, STK24, STK3
Sequence domains: Protein kinase domain

Ligands and Environments

1 bound ligand:
Ligand SQB 2 x SQB
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P21
Unit cell:
a: 55.875Å b: 93.21Å c: 61.303Å
α: 90° β: 92.191° γ: 90°
R-values:
R R work R free
0.208 0.205 0.263
Expression system: Escherichia coli

Quick links

Citations

2 review citations

The multiple roles of salt-inducible kinases in regulating physiology.
Jagannath et al. (2023)
1 more