7ax1

X-ray diffraction
3.3Å resolution

Crystal structure of the human CCR4-CAF1 complex

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-193797 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
CCR4-NOT transcription complex subunit 6 Chain: A
Molecule details ›
Chain: A
Length: 563 amino acids
Theoretical weight: 64.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9ULM6 (Residues: 1-557; Coverage: 100%)
Gene names: CCR4, CCR4a, CNOT6, KIAA1194
Sequence domains:
CCR4-NOT transcription complex subunit 7 Chain: B
Molecule details ›
Chain: B
Length: 290 amino acids
Theoretical weight: 33.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UIV1 (Residues: 2-285; Coverage: 100%)
Gene names: CAF1, CNOT7
Sequence domains: CAF1 family ribonuclease

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: C2
Unit cell:
a: 149.85Å b: 63.26Å c: 113.07Å
α: 90° β: 106.81° γ: 90°
R-values:
R R work R free
0.25 0.248 0.276
Expression system: Escherichia coli BL21(DE3)