Function and Biology Details
Reaction catalysed:
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
Coagulation factor Xa complex and antibody (preferred)
PDBe Complex ID:
PDB-CPX-208306 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Activated factor Xa heavy chain
Molecule details ›
Chains: C, E
Length: 241 amino acids
Theoretical weight: 27.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Trypsin
Length: 241 amino acids
Theoretical weight: 27.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P00742 (Residues: 235-475; Coverage: 53%)
Sequence domains: Trypsin
Factor X light chain
Molecule details ›
Chains: D, F
Length: 58 amino acids
Theoretical weight: 6.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Coagulation Factor Xa inhibitory site
Length: 58 amino acids
Theoretical weight: 6.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P00742 (Residues: 126-182; Coverage: 13%)
Sequence domains: Coagulation Factor Xa inhibitory site
