› 7a2n

X-ray diffraction
1.4Å resolution

Crystal structure of the Fyn SH3 domain A95S-D99T mutant in space group P21

Released:
DOI: 10.2210/pdb7a2n/pdb
PDB entry 7a2n coloured by chain, front view.
PDB entry 7a2n coloured by chain, side view.
PDB entry 7a2n coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Camara-Artigas A, Plaza-Garrido M, Salinas-Garcia MC

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138961 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase Fyn Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 60 amino acids
Theoretical weight: 6.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P06241 (Residues: 83-142; Coverage: 11%)
Gene name: FYN
Sequence domains: SH3 domain

Ligands and Environments

2 bound ligands:
Ligand FMT 9 x FMT
Ligand NA 12 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID30B
Spacegroup: P21
Unit cell:
a: 42.176Å b: 47.795Å c: 73.089Å
α: 90° β: 98.35° γ: 90°
R-values:
R R work R free
0.172 0.17 0.204
Expression system: Escherichia coli BL21(DE3)

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