› 6zpr

Solution NMR

Solution structure of MLKL executioner domain in complex with a covalent inhibitor

Released:
DOI: 10.2210/pdb6zpr/pdb
PDB entry 6zpr coloured by chain, ensemble of 20 models, front view.
PDB entry 6zpr coloured by chain, ensemble of 20 models, side view.
PDB entry 6zpr coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis.
Rübbelke M, Fiegen D, Bauer M, Binder F, Hamilton J, King J, Thamm S, Nar H, Zeeb M
Proc Natl Acad Sci U S A 117 33272-33281 (2020)
PMID: 33318170

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185458 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mixed lineage kinase domain-like protein Chain: A
Molecule details ›
Chain: A
Length: 157 amino acids
Theoretical weight: 18.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8NB16 (Residues: 2-154; Coverage: 33%)
Gene name: MLKL

Ligands and Environments

1 bound ligand:
Ligand QOK 1 x QOK
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 79%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

7 review citations

MLKL in cancer: more than a necroptosis regulator.
Martens et al. (2021)
6 more

1 mention without citation

Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis.
Rübbelke et al. (2020)