› 6zp2

Electron Microscopy
3.1Å resolution

Structure of SARS-CoV-2 Spike Protein Trimer (K986P, V987P, single Arg S1/S2 cleavage site) in Locked State

Released:
DOI: 10.2210/pdb6zp2/pdb
PDB entry 6zp2 coloured by chain, front view.
PDB entry 6zp2 coloured by chain, side view.
PDB entry 6zp2 coloured by chain, top view.
Source organism: Severe acute respiratory syndrome coronavirus 2
Primary publication:
A thermostable, closed SARS-CoV-2 spike protein trimer.
Xiong X, Qu K, Ciazynska KA, Hosmillo M, Carter AP, Ebrahimi S, Ke Z, Scheres SHW, Bergamaschi L, Grice GL, Zhang Y, Nathan JA, Baker S, James LC, Baxendale HE, Goodfellow I, Doffinger R, Briggs JAG
Nat Struct Mol Biol 27 934-941 (2020)
PMID: 32737467
Related structures: EMD-11334

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-144650 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1132 amino acids
Theoretical weight: 125.3 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 14-1141; Coverage: 90%)
Gene names: 2, S
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand BLA 3 x BLA
Ligand NAG 39 x NAG
Ligand EIC 3 x EIC
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-11334
Expression system: Homo sapiens

Quick links

Citations

26 review citations

The SARS-Coronavirus Infection Cycle: A Survey of Viral Membrane Proteins, Their Functional Interactions and Pathogenesis.
Wong et al. (2021)
25 more

20 mentions without citation

An Overview of the Crystallized Structures of the SARS-CoV-2.
Ionescu MI. (2020)
19 more