› 6zek

X-ray diffraction
2.1Å resolution

Crystal structure of mouse CSAD

Released:
DOI: 10.2210/pdb6zek/pdb
PDB entry 6zek coloured by chain, front view.
PDB entry 6zek coloured by chain, side view.
PDB entry 6zek coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structure and substrate specificity determinants of the taurine biosynthetic enzyme cysteine sulphinic acid decarboxylase.
Mahootchi E, Raasakka A, Luan W, Muruganandam G, Loris R, Haavik J, Kursula P
J Struct Biol 213 107674 (2021)
PMID: 33253877

Function and Biology Details

Reactions catalysed: 
L-aspartate = beta-alanine + CO(2)
3-sulfino-L-alanine = hypotaurine + CO(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190085 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cysteine sulfinic acid decarboxylase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 521 amino acids
Theoretical weight: 58.67 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9DBE0 (Residues: 1-493; Coverage: 100%)
Gene name: Csad
Sequence domains: Pyridoxal-dependent decarboxylase conserved domain

Ligands and Environments

4 bound ligands:
Ligand SO4 1 x SO4
Ligand CO 4 x CO
Ligand CL 13 x CL
Ligand GOL 4 x GOL
1 modified residue:
Ligand LLP 4 x LLP

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE MASSIF-1
Spacegroup: P21
Unit cell:
a: 72.94Å b: 113.26Å c: 113.37Å
α: 90° β: 95.808° γ: 90°
R-values:
R R work R free
0.181 0.179 0.235
Expression system: Escherichia coli

Quick links

Citations

1 review citation

The Disease-Modifying Role of Taurine and Its Therapeutic Potential in Coronavirus Disease 2019 (COVID-19).
van Eijk et al. (2022)
2 other articles