› 6zci

X-ray diffraction
1.98Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 4 Chain: A
Molecule details ›
Chain: A
Length: 148 amino acids
Theoretical weight: 17.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O60885 (Residues: 44-168; Coverage: 9%)
Gene names: BRD4, HUNK1
Sequence domains: Bromodomain

Ligands and Environments

1 bound ligand:
Ligand QFN 1 x QFN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 38.615Å b: 44.058Å c: 80.552Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.215 0.274
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases.
Ji et al. (2023)
3 other articles