› 6zcd

X-ray diffraction
1.8Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147446 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Derived from V114 peptide Chain: P
Molecule details ›
Chain: P
Length: 15 amino acids
Theoretical weight: 1.94 KDa
Source organism: synthetic construct
Expression system: Not provided
N-VEGF Chains: V, W
Molecule details ›
Chains: V, W
Length: 95 amino acids
Theoretical weight: 11.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P15692 (Residues: 219-313; Coverage: 24%)
Gene names: VEGF, VEGFA

Ligands and Environments

2 bound ligands:
Ligand MPD 5 x MPD
Ligand PO4 1 x PO4
1 modified residue:
Ligand NLE 1 x NLE

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P212121
Unit cell:
a: 53.644Å b: 55.699Å c: 77.21Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.19 0.242
Expression systems:
  • Not provided
  • Escherichia coli BL21(DE3)

Quick links

Citations

3 mentions without citation

A Structural Overview of Vascular Endothelial Growth Factors Pharmacological Ligands: From Macromolecules to Designed Peptidomimetics.
Ye et al. (2021)
2 more