6ymo

X-ray diffraction
2.02Å resolution

Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pS617 peptide

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-137449 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
14-3-3 protein zeta/delta Chains: A, B
Molecule details ›
Chains: A, B
Length: 235 amino acids
Theoretical weight: 26.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P63104 (Residues: 1-230; Coverage: 94%)
Gene name: YWHAZ
Sequence domains: 14-3-3 protein
Glucocorticoid receptor Chains: C, D
Molecule details ›
Chains: C, D
Length: 13 amino acids
Theoretical weight: 1.63 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P04150 (Residues: 611-623; Coverage: 2%)
Gene names: GRL, NR3C1

Ligands and Environments

2 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID30B
Spacegroup: P212121
Unit cell:
a: 72.285Å b: 104.351Å c: 112.429Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.212 0.234
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided